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''For adults treatment should be divided into Gonococcal and Non-Gonococcal 
====[[Gonococcal]]====
*[[Ceftriaxone]] 1g IV once daily
*[[Cefixime]] 400 mg PO BID is an option for outpatient therapy after initial 3 days of [[Ceftriaxone]]
====Non-Gonococcal====
*Treatment should cover [[S. aureus]], [[Streptococcus]], [[Pseudomonas]], [[Enterococcus]], [[ Borrelia burgdorferi| B. burgdorferi]]
*Vancomycin 15-20 mg/kg IV BID PLUS any of the following:
**[[Ceftriaxone]] 2g IV once daily 
**[[Cefepime]] 2g IV three times daily
**[[Ceftazidime]] 2g IV three times daily
**[[Ciprofloxacin]] 400mg IV three times daily
====Pediatrics====
*[[Ceftriaxone]] 1g IV once daily
====[[Sickle Cell]]====
''Coverage for [[Salmonella]] and [[Staphylococcus]] spp''
*[[Vancomycin]] 20mg/kg IV twice daily PLUS
**Ciprofloxacin 400mg IV three times daily OR
**Imipenem/cilastatin 1g IV three times daily