Ver el código de «Synthetic cannabinoids»

==Background==
*Common street names: spice, K2, Moon Rocks, Blue Lotus, many others 
*Active ingredients frequently change to avoid legal proscription 
*Generally contains cannabinoid receptor agonists (CB1 or CB2) that are far more potent than THC
*Does not show up on routine tox screen
*Generally smoked, but can be imbibed as a tea

==Clinical Features==
*Similar effect to marijuana at low doses, but may be more intense and cause an acute [[Excited delirium]]
*Typical onset of 10-30 min and taper over 1-2 hours 
*'''Tachycardia and hypertension''' common (distinguishing it from MJ use) 
*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, delirium
*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref>
*Serious bleeding as some synthetic cannibinoids contaminated with long acting vitamin K-dependent antagonists (brodifacoum) <ref>Moritz, E., Austin, C., Wahl, M., DesLauriers, C., Navon, L., Walblay, K., … Layden, J. (2018). Notes from the Field: Outbreak of Severe Illness Linked to the Vitamin K Antagonist Brodifacoum and Use of Synthetic Cannabinoids - Illinois, March-April 2018. MMWR. Morbidity and Mortality Weekly Report, 67(21), 607–608.</ref>

==Differential Diagnosis==
{{Sympathomimetic types}}

{{Drugs of abuse types}}

==Evaluation==
*Clinical diagnosis

==Management==
*Supportive care
*May require sedative agent such as benzodiazepines or antipsychotics, as well as physical restraints, if severely agitated and posing a threat to self and staff

==Disposition==
*Generally may be discharged once sober (assuming no adverse effects that would mandate admission)

==See Also==
*[[Sympathomimetic toxicity]]
*[[Marijuana]]

==References==
<references/>

[[Category:Toxicology]]