Ver el código de «Rifampin»

==General==
*Type: bactericidal [[antibiotic]]
*Dosage Forms: 150, 300; PO, IV
*Common Trade Names: Rifadin
==Pharmacology==
*Half-life: 1.5-5hours (increased if there is hepatic dysfunction)
**Rifampin autoinduces its own metabolism so half-life is decreased with subsequent dosing.
*Metabolism: Hepatic
*Excretion: Bile; Urine <30%
*Mechanism of Action: inhibits bacterial RNA synthesis

==Adult Dosing==



===Indications by Disease===
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 |?Has Dose=Dose
 |?Has Context=Context
 |format=table
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==Pediatric Dosing==

===Indications by Disease===
{{#ask: [[Has DrugName::Rifampin]] [[Has Population::Pediatric]]
 |?Treats disease=Disease
 |?Has Dose=Dose
 |?Has Context=Context
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==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*Lactation: Infant risk minimal
*Renal Dosing: 
**Adult
***CrCl <50: Consider decreasing dose 0-50%
***HD/PD: No supplment
**Pediatric
***CrCl <50: Consider decreasing dose 0-50%
***HD/PD: No supplment
*Hepatic Dosing
**Adult
***Avoid Use
**Pediatric
***Avoid Use

==Contraindications==
*Allergy to class/drug
*IM or SC administration
*Concomitant use with atazanavir, darunavir, fosamprenavir, saquinavir, tipranavir, rilpivirine or elvitegravir/cobicistat

==Adverse Reactions==
===Serious===
*[[Agranulocytosis]]
*[[DIC]]
*Hepatotoxicity
*Nephrotoxicity
*[[Thrombocytopenia]]
*[[Leukopenia]]
*[[Anemia]]
*Porphyria exacerbation
*Erythema multiforme
*[[Stevens-Johnson Syndrome]]
*Toxic epidermal necrolysis
*C. Diff associated diarrhea
*Psychosis
*[[Uveitis]]

===Common===
*Reddish-Orange body fluids
*[[Nausea]]/[[vomiting]]
*[[Diarrhea]]
*[[Headache]]
*[[Dizziness]]
*[[Fatigue]]
*Disequilibrium
*Weakness
*[[Pruritus]]
*Flushing
*Anorexia
*[[Abdominal pain]]
*[[Dyspnea]]
*Contact lens staining

==Acute Overdose==
*Diarrhea is unique to rifampin toxicity in comparison to other antituberculous medications<ref>Broadwell R. et al. Suicide by rifampin overdose. JAMA. 1978; 240:2283.13.</ref>

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||X1
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||I
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||'''S'''
|-
| ||[[CA-MRSA]]||'''S'''
|-
| ||[[Staph. Epidermidis]]||'''S'''
|-
| ||[[C. jeikeium]]||'''S'''
|-
| ||[[L. monocytogenes]]||'''S'''
|-
| Gram Negatives||[[N. gonorrhoeae]]||X2
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||R
|-
| ||[[Klebsiella]] sp||R
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||I
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||X1
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||R
|-
| ||[[Shigella]] sp||R
|-
| ||[[Proteus mirabilis]]||X1
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||X1
|-
| ||[[Morganella sp.]]||X1
|-
| ||[[Citrobacter freundii]]||X1
|-
| ||[[Citrobacter diversus]]||X1
|-
| ||[[Citrobacter sp.]]||X1
|-
| ||[[Aeromonas sp]]||X1
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||X1
|-
| ||[[Yersinia enterocolitica]]||X1
|-
| ||[[Francisella tularensis]]||'''S'''
|-
| ||[[Brucella sp.]]||''S+'''
|-
| ||[[Legionella sp.]]||X1
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X2
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||X1
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==

==References==
<references/>

[[Category:Pharmacology]]
[[Category:ID]]