Ver el código de «Prostaglandin E1»

==General==
*AKA: aloprostadil
*Type: smooth muscle relaxer, vasodilator
*Dosage Forms: intravenous, penile injection, penile suppository
*Common Trade Names: [https://alprostadil.org Alprostadil], Prostin VR, Caverject, Muse, Edex
*Uses: maintenance of [[patent ductus arteriosus]] in neonates with duct-dependent congenital heart defects; treatment of erectile dysfunction in adults

==Adult Dosing==

==Pediatric Dosing<ref> Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey S, Lee W, Michelfelder EC Sr, Rempel GR, Silverman NH, Spray TL, Strasburger JF, Tworetzky W, Rychik J. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing.Circulation. 2014 May 27;129(21):2183-242. doi: 10.1161/01.cir.0000437597.44550.5d. Epub 2014 Apr 24.</ref>==
*Start infusion at 0.05 mcg/kg/min IV 
**Titrate to 0.1 mcg/kg/min as tolerated, monitoring for hypotension (and apnea)

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*Lactation: infant risk cannot be ruled out
*Renal Dosing
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
*Beware of three common side effects that may require further resuscitation<ref>Martin RJ et al. Pathophysiologic Mechanisms Underlying Apnea of Prematurity. NeoReviews Vol.3 No.4 April 2002.</ref><ref>Segar JL. Protocol for Use of Prostaglandin E. University of Iowa Stead Family Children's Hospital. Accessed Dec 2016. https://uichildrens.org/health-library/protocol-use-prostaglandin-e?id=234424</ref>:
**Apnea (12%), which requires respiratory monitoring with ETCO2 capnography, potential mechanical ventilation, and/or ALS/PALS transport if needing transfer to higher level of care
**Peripheral flushing with or without hypotension (10%), which requires fluid resuscitation
**[[Fever]] (14%)
*Others:
**[[Hypotension]]
**[[Bradycardia]]
**[[Seizures]]

==Pharmacology==
*Half-life: 5-10m
*Metabolism: Lung
*Excretion: Renal
*Mechanism of Action: synthetic of endogenous prostaglandin

==Comments==
*Cyanotic neonates with ductal-dependent lesions typically respond within 10-15 minutes, but may not show response until several hours after the start of infusion. 

==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

{{#ask:[[Has DrugName::Prostaglandin E1]]
 |?Has Indication=Indication
 |?Has Dose=Dose
 |?Has Context=Context
 |?Has Route=Route
 |?Has Population=Population
 |format=table
 |headers=plain
 |mainlabel=-
 |sort=Has Indication
 |limit=50
}}

==See Also==
*[[Tetralogy of fallot]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Pediatrics]]
[[Category:Cardiology]]