Ver el código de «Pramipexole»

==Administration==
*Type: Dopamine agonist
*Dosage Forms: TAB, ER TAB
*Routes of Administration: Oral
*Common Trade Names: Mirapex

==Adult Dosing==
===[[Parkinson's Disease]]===
*Immediate release
**0.5-1.5 mg PO TID
***Start 0.125 mg PO TID x7 days then 0.25 mg x7 days then increase 0.75 mg/day q7days to goal dose
***Max: 4.5 mg/day
*Extended Release
**0.375-4.5 mg ER PO daily
***Start 0.375 mg ER PO daily then titrate q7 days as above
===Restless legs syndrome===
*0.125-0.5 mg PO qhs
===Rapid eye movement sleep behavior disorder===
*0.125-1.5 mg PO qhs

==Pediatric Dosing==
===Restless leg syndrome===
*5+ yo
**0.125-0.375 mg PO qhs

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Category C
*Caution advised during pregnancy
*Risk of embryo-fetal death based on animal data at 4-5 MRHD

===Lactation risk===
*Consider alternative
*Theoretical decreased milk production based on decreased prolactin levels

===Renal Dosing===
*Adult:
**CrCl 30-50: Start 0.125 mg BID or 0.375 gm ER qod then titrate
**CrCl <30: Avoid use
*Pediatric: Dose adjustment may be required, but has not been defined.

===Hepatic Dosing===
*Adult: No adjustment
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug
*Avoid abrupt withdrawal

==Adverse Reactions==
===Serious===
*Sudden sleep episodes
*[[Hypotension]], orthostatic
*[[Syncope]]
*[[Dyskinesia]]
*Extrapyramidal symptoms
*[[Hallucination]]
*[[Rhabdomyolysis]]
*[[NMS]]-like symptoms if acute withdrawal

===Common===
*[[Hypotension]]
*[[Dyskinesia]], Extrapryamidal symptoms
*[[Nausea]], [[constipation]], [[diarrhea]], [[vomiting]]
*[[Insomnia]], [[hallucination]], [[headache]], [[fatigue]]
*Confusion, abnormal dreams, amnesia, compulsive behaviors
*Urinary frequency
*Muscle spasm, peripheral edema

==Pharmacology==
*Half-life: 8h (IR); 8.5h (ER)
*Metabolism: None
*Excretion: Urine 90%

==Mechanism of Action==
*Stimulates dopamine receptors

==Comments==


==See Also==
*[[Parkinson's disease]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Neurology]]