Ver el código de «Post-hypoxic myoclonus»

==Background==
*Myoclonus (irregular muscle contractions) after hypoxic brain injury due to [[cardiac arrest]]
*Acute: onset within 48h of injury
**Post-[[hypoxic]] myoclonic status: acute myoclonus lasting >30min
***Difficult to control, associated with poor prognosis
***Occurs in 30-40% of comatose cardiac arrest survivors 
*Chronic: onset days-weeks after cardiac arrest in patients who regained consciousness (AKA Lance-Adams syndrome)

==Clinical Features==
*Acute:
**Recent (within 48h) hypoxic brain injury with neuronal necrosis
**Abrupt onset of irregular muscle contractions, focal or generalized
*Post-hypoxic status myoclonus
**Onset usually within 12-24h of injury
**Generalized, multifocal clonus
*Chronic 
**Onset days-weeks after arrest
**Awareness preserved
**Typically intention myoclonus

==Differential Diagnosis==
*[[Seizure]]

==Evaluation==
*EEG (r/o seizure)
*Evaluate for alternative etiologies

==Management==
*Acute/status
**Difficult and of limited utility
**Consider [[benzodiazepines]], [[propofol]], [[phenytoin]], [[valproate]]
**Address [[goals of care]] given sign of poor prognosis
*Chronic/lance-adams syndrome
**[[Valproate]], [[clonazepam]], and/or [[levetiracetam]] may help control myoclonus

==Disposition==


==See Also==
*[[Hypoxemia]]

==External Links==


==References==
<references/>
*LITFL: https://litfl.com/post-hypoxic-myoclonus/
[[Category:Neurology]]