Ver el código de «Penicillin G Procaine»

==General==
*Type: Natural [[Penicillin]]
*Routes of Administration: IM
*Common Trade Names:

==Adult Dosing==
===[[Anthrax]]===
*Inhalational (Postexposure Prophylaxis)
**1,200,000 units IM q12 hours x 60 days (see below)
**Info: Total treatment duration = 60 days. Do not give IM for over 2 weeks, switching alternative treatment to complete course
*Cutaneous, Nonsevere (Treatment)
**600,000-1,200,000 units/day IM

===[[Endocarditis]] by susceptible [[Streptococcus viridans]]===
*1.2 million units IM q6 hours x 2-4 weeks + [[aminoglycoside]]

===Neurosyphilis===
*2.4 million units/day IM + 500mg probenecid PO QID x 10-14 days
*Info: [[Penicillin G]] aqueous I.V. is preferred

===Whipple's Disease===
*1.2 million units/day + streptomycin x 10-14 days
*Followed by [[trimethoprim/sulfamethoxazole]] or doxycycline x 1 year

===Indications by Disease===
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==Pediatric Dosing==
''Avoid use in neonates: increased risk of sterile abscesses and procaine reactions''

===Indications by Disease===
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===General===
*25,000-50,000 units/kg/day divided 1-2 times/day
*First Dose: 25,000-50,000 units/kg x 1
*Max: 4.8 million units/day

===[[Anthrax]]===
*Inhalational (postexposure prophylaxis)
**25,000 units/kg IM q12 hours
**Max: 1,200,000 units q12 hours
**Info: Total treatment duration = 60 days. Do not give IM for over 2 weeks, switching alternative treatment to complete course

===[[Syphilis]] (Congenital)===
*50,000 units/kg/day IM daily x 10 days
*If >1 day of therapy is missed, restart entire course of treatment

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Category]]: B
*Lactation: Use caution
*Renal Dosing
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric

==Contraindications==
*Allergy to class/drug
*Avoid use in neonates

==Adverse Reactions==
===Serious===
*Procaine reactions: Immediate toxic reactions, particularly when a large single dose is administered (4.8 million units); mental disturbances including anxiety, confusion, agitation, depression, weakness, seizures, hallucinations, combativeness, and fear
*Jarisch-Herxheimer reaction with syphilis treatment
*Pseudomembranous colitis

===Common===
*Rash, urticaria, exfoliative dermatitis
*Serum-sickness like reaction

==Pharmacology==
*Half-life: 30m
*Metabolism: Hepatic
*Excretion: Urinary
*Mechanism of Action: Bactericidal; Interferes with cell wall mucopeptide synthesis during active multiplication

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>
[[Category:Pharmacology]]
[[Category:ID]]