Ver el código de «Paraneoplastic syndromes»

==Background==
*Syndrome associated with cancer, but not due to direct, local effects of neoplasm
*Result of hormones/substances secreted by malignant cells or immune response to cancer cells/products

==Examples==

{| {{table}}
| align="center" style="background:#f0f0f0;"|'''Syndrome'''
| align="center" style="background:#f0f0f0;"|'''Main causal cancers'''
| align="center" style="background:#f0f0f0;"|'''Mechanism'''
|-
| [[Cushing syndrome]]||Small cell lung cancer, pancreatic carcinoma, neural tumors, thymoma||Ectopic ACTH/ACTH-like substance production
|-
| [[SIADH]]||Small cell lung cancer, CNS malignancies||Ectopic ADH production
|-
| [[Hypercalcemia of malignancy|Hypercalcemia]]||Lung (esp. [[squamous cell carcinoma|SCC]]), breast, renal/bladder, ovarian, [[multiple myeloma]], adult T cell [[leukemia]]/[[lymphoma]], [[squamous cell carcinoma]]||
|-
| [[Hypoglycemia]]||Sarcomas, insulinoma, [[hepatocellular carcinoma]]||Insulin/IGF production
|-
| [[Carcinoid syndrome]]||Bronchial adenoma, pancreatic and gastric carcinoma||Serotonin or bradykinin production
|-
| Hyperaldosteronism||Adrenal adenoma, [[non-Hodgkin's lymphoma]], ovarian carcinoma, lung cancer||increased/ectopic aldosterone production
|-
| [[Lambert-Eaton myasthenic syndrome]]||Small cell lung cancer||Immune-mediated
|-
| Paraneoplastic cerebellar degeneration||Lung, ovarian, breast cancers, [[Hodgkin's lymphoma]]||
|-
| [[Opsoclonus]] myoclonus syndrome||[[neuroblastoma (peds)|Neuroblastoma]] (occurs in 2-3% of peds cases), breast, ovarian, small-cell carcinoma||Autoimmune; s/sx include opsoclonus/myoclonus and other cerebellar dysfunction, aphasia, lethargy/irritability
|-
| Brain-stem or [[limbic encephalitis]]||Small cell lung cancer, germ-cell testicular tumors||Autoantibodies against intracellular neuronal proteins
|-
| [[Anti-NMDA receptor encephalitis]]||Gyn tumors (esp. teratomas)||Anti-NMDA receptor auto-antibodies
|-
| [[Polymyositis]]/[[Dermatomyositis]]||[[Lymphoma]], lung, pancreatic, stomach, bladder, ovarian||autoimmune
|-
| [[Acanthosis nigricans]]||Gastric, lung, uterine||Epidermal growth factor secretion
|-
| Misc. derm conditions (Sweet's syndrome, Leser-Trelat sign, [[pyoderma gangrenosum]], florid cutaneous papillomatosis, necrolytic migratory erythema, hypertrichosis)||lung, GI adenocarcinomas, breast and GU cancers, [[lymphoma]]||
|-
| [[VTE]], [[thrombophlebitis]]||any advanced cancer. Pancreatic and bronchogenic carcinomas associated w/trousseau's sign||Hypercoagulability
|-
| [[Polycythemia]]||Renal cell carcinoma, cerebellar hemangioma, [[hepatocellular carcinoma]]||Increased erythropoietin production
|-
| Granulocytosis||various||C-GSF
|-
| Membranous [[glomerulonephritis]]||||tumor antigens/immune complexes
|-
| Thymoma-associated multiorgan autoimmunity||Thymoma||similar to [[GVHD]]
|}

==References==
<references/>

[[Category:Heme/Onc]]