Ver el código de «Omeprazole»

==Administration==
*Type: [[Proton pump inhibitor]] (PPI)
*Dosage Forms: Tablets or capsules of 10, 20, 40, 80mg. Powder of omeprazole sodium for IV.
*Routes of Administration: PO, IV
*Common Trade Names: Prilosec

==Adult Dosing==
===[[GERD]]===
*20mg PO once daily, taken about 1 hour before meals

===[[Peptic ulcers]]===
*40mg PO daily

===Zollinger Ellison syndrome===
*60mg PO q8-24h

==Pediatric Dosing==
===GERD===
*<1 year: Safety and efficacy not established
*5-10 kg: 5 mg PO qDay
*10-20 kg: 10 mg PO qDay
*>20 kg: 20 mg PO qDay
===Erosive Esophagitis===
*<1 month: Safety and efficacy not established
*Aged 1 month to <1 year
**3 to <5 kg: 2.5 mg qDay
**5 to <10 kg: 5 mg qDay
**≥10 kg: 10 mg qDay
*Aged 1-16 years
**5 to <10 kg: 5 mg PO qDay
**10 to <20 kg: 10 mg PO qDay
**≥20 kg: 20 mg PO qDay

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: May be present in milk
===Renal Dosing===
*No adjustment
===Hepatic Dosing===
*Not studied

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Agranulocytosis
*Fractures, osteoporosis-related
*Hepatotoxicity
*Pancreatitis
*Interstitial nephritis
*Rhabdomyolysis

===Common===
*Headache, dizziness
*Nausea/vomiting, diarrhea, abdominal pain, flatulence, acid regurgitation, constipation
*URI, cough
*Rash
*Gastric polyps
*Alopecia
*Atrophic gastritis

==Pharmacology==
*Half-life: 1-1.2 hours <ref>Prilosec Prescribing Information. AstraZeneca Pharmaceuticals.</ref>
*Metabolism: Hepatic (CYP2C19, CYP3A4) <ref>Prilosec Prescribing Information. AstraZeneca Pharmaceuticals.</ref>
*Excretion: Urine

==Mechanism of Action==
*PPI; binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in suppression of basal and stimulated acid secretion

==Comments==

==See Also==
*[[Proton-pump inhibitor]]

==References==
<references/>
[[Category:Pharmacology]]
[[Category:GI]]