Ver el código de «Nitroglycerin»

==General==
*Type: vasodilator; stimulates cGMP production causing vascular smooth muscle relaxation
*Dosage Forms: SL, IV
*Common Trade Names: Nitrolingual, NitroMist, Nitrostat

==Adult Dosing==
===Angina, acute===
*0.3 - 0.6mg SL q5min, max: 3 doses within 15 min
*IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min.

===[[Hypertension]]===
*5-200 mcg/min IV, start 5 mcg/min IV and increase 5 mcg/min q3-5min

==Pediatric Dosing==
===[[Hypertension]]/[[CHF]]===
*1-5 mcg/kg/min IV, start 0.25-0.5 mcg/kg/min, max: 20 mcg/kg/min

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*Lactation: safety unknown
*Renal Dosing
**Adult: no adjustment
**Pediatric: no adjustment
*Hepatic Dosing
**Adult: not defined
**Pediatric: not defined

==Contraindications==
*Allergy to class/drug
*Pericardial tamponade
*Severe anemia
*[[Sildenafil]] use within the past 24 hours or tadalafil within the past 48 hours<ref>Kloner RA, Hutter AM, Emmick JT, Mitchell MI, Denne J, Jackson G. Time course of the interaction between tadalafil and nitrates. J Am Coll Cardiol. 2003 Nov 19;42(10):1855-60.</ref><ref>Cheitlin MD, Hutter AM Jr, Brindis RG, et al. ACC/AHA/[https://nizagara-online.net Nizagara-online.net] expert consensus document: use of sildenafil (Viagra) in patients with cardiovascular disease: American College of Cardiology/American Heart Association. J Am Coll Cardiol 1999;33:273-82.</ref>
*[[Methemoglobinemia]]
*Caution in hypotension

==Adverse Reactions==
===Serious===
*hypotension
*bradycardia
*methemoglobinemia
===Common===
*headache
*dizziness
*flushing
*hypotension
*reflex tachycardia
*edema

==Pharmacology==
*Half-life: 1-3 min
*Metabolism: liver, erythrocytes, vascular walls
*Excretion: urine
*Mechanism of Action: stimulates cGMP production resulting in vascular smooth muscle relaxation


==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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==See Also==

==External Links==
*[https://emcrit.org/emcrit/scape/ EMCrit: Sympathetic Crashing Acute Pulmonary Edema (SCAPE)]

==References==
[[Category:Pharmacology]]
[[Category:Cardiology]]