Ver el código de «Nifurtimox»

==Administration==
*Type: [[Antiparasitic]]
*Dosage Forms:
*Routes of Administration: PO
*Common Trade Names: Lampit

==Adult Dosing==
*8-10 mg/kg/day PO divided q6-8hr for 90-120 days

==Pediatric Dosing==
*1-10 years: 15-20 mg/kg/day PO divided q8hr
*11-16 years: 12.5-15 mg/kg/day PO divided q8hr x90 days

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Unknown risk, no human data available

===Lactation risk===
*Unknown

===Renal Dosing===
*Contraindicated in renal impairment

===Hepatic Dosing===
*Contraindicated in hepatic impairment

==Contraindications==
*Allergy to class/drug
*Active or history of peripheral neuropathy
*Active or history of seizures or cerebral impairment, behavioral disorders, or psychoses
*Hepatic impairment
*Renal impairment

==Adverse Reactions==
===Serious===
*Seizures
*Pleural effusion

===Common===
*Anorexia (can be significant and limit completion of therapy)
*Ataxia, paresthesia, polyneuritis, tremor
*Depression, fatigue, sleep disorder, weakness
*Headache
*Memory impairment
*Rash, pruritic dermatitis
*Gastralgia, vomiting
*Myalgia
*Pulmonary infiltrates

==Pharmacology==
*Half-life:  2.95 +/- 1.19 hr
*Metabolism: Hepatic
*Excretion: Urinary

==Mechanism of Action==
*Inhibits trypanothione reductase, a parasite-specific antioxidant defense enzyme

==Comments==
*Investigational status in the US<ref>https://reference.medscape.com/drug/lampit-nifurtimox-342663#0</ref>

==See Also==
*[[Chagas disease]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:ID]]