Ver el código de «Myelodysplastic syndrome»

==Background==
*Acquired clonal disorder of hematopoietic stem cells, leading to hypercellular marrow, abnormal cell morphology, and cytopenias
*Idiopathic or secondary to chemotherapy or radiation
*May evolve into [[acute myeloid leukemia]]

==Clinical Features==
*Asymptomatic
*Signs/symptoms of [[anemia]]
*Signs/symptoms of [[infection]] if [[neutropenia|neutropenic]]
*Signs/symptoms of [[thrombocytopenia]]
*Splenomegaly

==Differential Diagnosis==
*[[Acute leukemia]], infiltrative malignancy (e.g. [[lymphoma]], [[multiple myeloma]], metastatic carcinoma)
*[[Myelodysplastic syndrome]], myelofibrosis
*[[Aplastic anemia]]
*[[Paroxysmal nocturnal hemoglobinuria]]
*Medication/radiation induced
*[[Tuberculosis]], [[AIDS]]
*[[Leishmaniasis]], [[brucellosis]], [[histoplasmosis]]. 
*Viruses causing [[aplastic anemia]] ([[viral hepatitis|hepatitis]], [[Epstein-Barr virus]], [[HIV]], [[parvovirus B19]])
*[[Systemic lupus erythematosus]]
*Hypersplenism

==Evaluation==
*CBC
**Marked normo or macrocytic [[anemia]]
**[[Leukopenia]], commonly with abnormal neutrophil morphology
**[[Thrombocytopenia]]
*Peripheral smear
*Type and screen
*Infectious workup, if signs of infection present
*Evaluate for other causes of symptoms

==Management==
*See [[anemia]], [[thrombocytopenia]], [[neutropenic fever]]
*Outside of ED, treatments may include
**EPO, filgrastim, romiplostim, eltrombopag
**Lenalidomide
**[[Stem cell transplant]]

==Disposition==

==See Also==
*[[Pancytopenia]]
*[[Oncologic emergencies]]

==External Links==

==References==
<references/>

[[Category:Heme/Onc]]