Ver el código de «Multiple endocrine neoplasia»

==Background==
[[File:Multiple endocrine neoplasia.png|thumb|MEN findings by type.]]
*Autosomal dominant predisposition to tumors within endocrine organs/glands
*Classified into two distinct syndromes, multiple endocrine neoplasia type 1 (MEN1), and multiple endocrine neoplasia type 2 (MEN2)
**Type 2 further subclassified into MEN2A and MEN2B

==Clinical Features==
*MEN1:
**Primary [[hyperparathyroidism]]
***Most common manifestation of MEN1<ref>Al-Salameh A, Cadiot G, Calender A, Goudet P, Chanson P. Clinical aspects of multiple endocrine neoplasia type 1. Nat Rev Endocrinol. 2021 Apr;17(4):207-224. doi: 10.1038/s41574-021-00468-3. Epub 2021 Feb 9. PMID: 33564173.</ref>
**Pituitary adenomas
**Pancreatic islet cell/GI endocrine tumors (e.g., [[Zollinger-Ellison syndrome]], [[Insulinoma]])
*MEN2A:
**Primary [[hyperparathyroidism]]
**Medullary thyroid cancer
**[[Pheochromocytoma]]
*MEN2B:
**Medullary thyroid cancer
**[[Pheochromocytoma]]
**Mucosal neuromas, often involving the lips and tongue

==Differential Diagnosis==


==Evaluation==
*MEN1: Should be suspected in any patient with two or more primary MEN1 tumor types
*MEN2: Should be suspected in any patient with medullary thyroid cancer or [[pheochromocytoma]]
===Workup===

===Diagnosis===
*Clinical diagnosis with confirmatory genetic testing
**MEN1: Germline MEN1 mutation
**MEN2: Germline RET mutation

==Management==


==Disposition==


==See Also==


==External Links==


==References==
<references/>

[[Category:Heme/Onc]]