Ver el código de «Marijuana toxicity»

==Background==
*Marijuana is the most commonly used illegal substance in the world<ref>Leggett T, United Nations Office on Drugs and Crime. A review of the world cannabis situation. Bull Narc 2006; 58:1.</ref>
*THC concentrations have been steadily increasing in multiple formulations due to strain engineering
*Pediatric overdoses increasing, though unintentional, due to increased legalization and access

==Clinical Features==
*Excessive and purposeless motor activity of the extremities (hyperkinesis)
*[[Lethargy]] 
*[[Tachycardia]]
*[[Hypertension]] or orthostatic [[hypotension]]
*[[Tachypnea]]
*Conjunctival injection
*Dry mouth
*Increased appetite
*[[Nystagmus]]
*[[Ataxia]]
*[[Dysarthria|Slurred speech]]

==Differential Diagnosis==
*[[Hypoglycemia]]
*[[Meningitis]]]/[[Encephalitis]]
*[[TBI]]
*Drugs - [[Opioid toxicity|Opioids]], [[Antihistamines]], [[Anticholinergic toxicity|Anticholinergics]], [[Antipsychotics]]
*[[CO poisoning]]

{{Drugs of abuse types}}

==Evaluation==
*Clinical Diagnosis
*[[Urine toxicology screen]] helpful, but can be negative with synthetic cannabis

===Peak Plasma Concentration Time<ref>Kim HS, Monte AA. Colorado cannabis legalization and its effect on emergency care. Ann Emerg Med. 2016;68(1):71-75</ref>===
*Inhalation: 3-10 minutes
*Ingestion/oral: 1-6 hours 
*Intravenous: 10 minutes 
*Rectal: 2-8 hours

==Management==
*Supportive care, if concerned for mixed ingestion, try other reversal agents

==Disposition==
*Discharge when clinically sober

==See Also==
*[[Cannabinoid hyperemesis syndrome]]
*[[Synthetic cannabinoids]]

==External Links==


==References==
<references/>

[[Category:Pharmacology]]
[[Category:Toxicology]]