Ver el código de «Magnesium sulfate»

''See [[critical care quick reference]] for drug doses by weight.''
==General==
*Type: [[Antiarrhythmics]]
*Dosage Forms: IV
*Common Trade Names: None

==Adult Dosing==
===[[Cardiac arrest]]===
*Loading dose = 1-2gm in 10mL [[D5W]] over 1-2min

===Spontaneous circulation===
*Loading dose = 1-4gm in 50-100 [[D5W]] over 20-60 min

===[[Eclampsia]]===
*Initial: 4-6 g IV magnesium sulfate (Dilute the 50% solution of 400mg elemental magnesium, to a 10% or 20% solution) and give over 20 to 30 minutes 
*Maintenance: 1 to 2 g/hr IV until paroxysms cease
'''OR''' 
*If no IV Access, give Magnesium sulfate 50% solution IM 10g Loading Dose (5g in each buttock)
*Maintenance: followed by 5 g IM q 4 hours
(Note: Use IM if no IV, No data on IO Route for Ecclampsia)

==Pediatric Dosing==
*[[Torsades]]: 25 to 50mg/kg rapid infusion over several minutes

===Cardiac===
*25-50mg/kg IV x 1
''See [[critical care quick reference]] for drug doses by weight.''

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D (despite being drug of choice for [[eclampsia]]!)
*Lactation: infant risk minimal
*Renal Dosing: for severe renal impairment, max dose 20g/48 hours
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric

==Indications==
*[[QT prolongation]]
*[[Torsades]]
*Refractory v-tach/fib (regardless of Mg level)
*[[Eclampsia]]
*[[Hypomagnesemia]]
*Barium poisoning

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*[[Hypotension]] (rare)
*Heart block
*CNS depression
*Respiratory depression

===Common===

==Pharmacology==
*Half-life: 
*Onset of action = Immediate
*Duration of action = 30min
*Metabolism: 
*Excretion: Renal

===Mechanism of Action===
*Increases vasomotor tone
*Prolongs AV conduction; prolongs refractoriness

==See Also==
*[[Hypermagnesemia]]
*[[Hypomagnesemia]]
*[[QT prolongation]]
*[[Eclampsia]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:FEN]]
[[Category:Cardiology]]