Ver el código de «Lupus anticoagulant»

==Background==
*Misnomer as it is a prothrombotic agent in-vivo (anticoagulant in-vitro in the lab)
*Most patients do not actually have [[SLE]] (small proportion develop disease), but SLE patients more likely to develop lupus anticoagulant
*Included in [[antiphospholipid syndrome]] (APS), where there are directed antibodies against membrane anionic phospholipids, or their associated plasma proteins
**Increases aPTT

==Clinical Features==
*Recurrent [[arterial thrombosis|arterial]]/[[venous thrombosis|venous thromboembolism]]
*Recurrent [[miscarriage|fetal loss]]

==Differential Diagnosis==
{{Increased bleeding DDX}}

==Evaluation==

==Management==
*Thrombosis (e.g. extremity [[phlebitis]] or dural [[sinus vein thrombosis]])
**[[Heparin]] IV/SQ followed by [[warfarin]] +/- [[ASA]]
**Goal INR
***Venous 2.0-3.0
***Arterial 3.0
***Recurrent 3.0-4.0

===Pregnancy===
''[[Miscarriage]] is common''
*Prophylaxis for most women
*Patients with pregnancy loss
**Prophylactic [[heparin]] and low-dose [[ASA]]
*Patients with history of thrombosis
**Therapeutic [[heparin]]

===Prophylaxis===
*Eliminate risk factors (OCPs, smoking, hypertension and HL)
*Low-dose [[ASA]]

==Disposition==

==See Also==
*[[Coagulopathy (Main)]]

==References==
<references/>
[[Category:Heme/Onc]]