Ver el código de «Lofexidine»

==Administration==
*Type: Central alpha<sub>2</sub> adrenergic agonist, opioid withdrawal
*Dosage Forms: 0.18 mg tablets
*Routes of Administration: oral
*Common Trade Names: Lucemyra

==Adult Dosing==
===Opioid Withdrawal===
0.54 mg PO q6h during peak withdrawal symptoms
*Do not exceed 2.88 mg (16 tablets) per day
*Do not exceed 0.72 mg (4 tablets) in a single dose<br />
May be continued for up to 14 days, gradually reduce dose over 2-4 days to mitigate Lofexidine withdrawal symptoms

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Limited information

===Lactation risk===
*Unknown

===Renal Dosing===
*eGFR 30 to 90: 0.36 mg q6h
*eGFR <30: 0.18 mg q6h
*ESRD/HD: 0.18 mg q6h, minimally dialyzable

===Hepatic Dosing===
*Mild impairment (Child-Pugh class A): no adjustment
*Moderate impairment (Child-Pugh class B): 0.36 mg q6h
*Severe impairment (Child-Pugh class C): 0.18 mg q6h

==Contraindications==
*Allergy to class/drug
*Caution with prior history or family history of long QT syndrome

==Adverse Reactions==
===Serious===
*[[Torsades de pointes]]

===Common===
*Orthostatic hypotension
*Bradycardia
*Dizziness
*Somnolence
*Sedation
*Insomnia
*Dry mouth

==Pharmacology==
*Half-life: 11 to 13 hours (first dose), 17 to 22 hours (steady state)
*Metabolism: First pass associated with gut absorption, hepatic via CYP2D6 (primary), CYP1A2, and CYP2C19
*Excretion: Urine (94%), Feces (1%)

==Mechanism of Action==
*Centrally acting alpha2 agonist that decreases sympathetic output and symptoms of withdrawal
*Thought to have less anti-hypertensive activity than Clonidine

==Comments==
*Patient's may respond to lower opioid doses increasing risk of overdose
*0.18 mg tablet = $24.83

==See Also==
[[Opioid withdrawal]]

==References==
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[[Category:Pharmacology]]