Ver el código de «Local anesthetics»

==Background==
*Am'''i'''des have two "i's" (pr'''i'''locaine, l'''i'''docaine, etc)
*Esters have one "i" (tetracaine, procaine, benzocaine, etc)
*Ester local anesthetics more likely to cause allergic reaction due to metabolite PABA<ref>GlobalRPH. Local Anesthetics (ester and amide-type). http://www.globalrph.com/local-anesthetics.htm.</ref>
*If patient allergic to amides and esters, consider local [[Diphenhydramine]] (Na blocker)<ref>Pavlidakey PG et al. Diphenhydramine as an Alternative Local Anesthetic Agent. J Clin Aesthet Dermatol. 2009 Oct; 2(10): 37–40.</reF>
**Sodium channel blocker mechanism
**1-2 mL of 1% diphenhydramine at a time, to not exceed excessive sedation dose
**Typical vial is 50 mg/mL, so to make 10 mg/mL:
***10 mL NS removed from 50 mL vial
***Add 10 mL of 50 mg/mL diphenhydramine to 40 mL of NS
***Sedation is dose related and is similar to what would be expected for IM doses
***Relative contraindications are the same for IM diphenhydramine administration
{{Maximum doses of anesthetic agents}}

==Side Effects==
*CNS
**Perioral numbness
**[[Seizure]]
*Cardiovascular
**AV blocks
**VT and VF
**Asystole
*Allergic reaction
*[[Methemoglobinemia]]

==See Also==
*[[Local Anesthetic Systemic Toxicity (LAST)]]

==References==
<references/>
[[Category:Pharmacology]]