Ver el código de «Lithium»

==Administration==
*Type: Anti[[bipolar disorder|manic]] agent
*Dosage Forms:
*Routes of Administration: oral
*Common Trade Names: 

==Adult Dosing==
*Maintenance: 300mg PO 3 to 4 times daily; desired serum lithium level 0.6 to 1.2 mEq/L
*Acute manic episode: 600mg PO 3 times daily; desired serum lithium level 1 to 1.5 mEq/L
==Pediatric Dosing==
''Safety/efficacy not established in children <12yo''
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D
*[[Lactation risk categories|Lactation risk]]: infant risk cannot be ruled out
===Renal Dosing===
*Adult: Contraindicated if renal function unstable<ref>https://reference.medscape.com/drug/eskalith-lithobid-lithium-342934#5</ref>
===Hepatic Dosing===
*Adult: Not established

==Contraindications==
*Allergy to class/drug
*Unstable renal function
*Severe dehydration
*Sodium depletion
*Severe debilitation
*Concurrent diuretics
*Severe cardiovascular disease
*1st trimester pregnancy

==Adverse Reactions==
===Serious===
*Toxicity (see [[Lithium toxicity]])
*Seizure, ataxia, raised ICP
*Angioedema
*Erythema multiforme

===Common===
*Hypothyroidism, weight gain
*Nephrotoxicity
*Fine tremor, hyperreflexia
*Leukocytosis
*Nausea, gastritis
*Acne


==Pharmacology==
*Half-life: 14-50hr
*Metabolism: Renal
*Excretion: Renal

==Mechanism of Action==
*Exact mechanism unclear; inhibits postsynaptic D2 receptor supersensitivity, alters cation transport in nerve cells, influences serotonin/norepinephrine reuptake, inhibits phosphatidylinositol cycle second messenger systems<ref>https://reference.medscape.com/drug/eskalith-lithobid-lithium-342934#5</ref>

==Comments==

==See Also==
*[[Lithium toxicity]]
==References==
<references/>
[[Category:Pharmacology]]
[[Category:Psychiatry]]