Ver el código de «Ketoprofen»

==Administration==
*Type: [[NSAID]]
*Dosage Forms: Cap 50mg, 75mg; ER Cap 200mg
*Routes of Administration: Oral
*Common Trade Names: Oruvail

==Adult Dosing==
===Pain, mild-moderate===
*50mg PO q6-8h
**Max: 300mg/day
===[[Osteoarthritis]]===
*75mg PO TID or 50mg PO qid or 200mg ER PO daily
**Max: 300mg/day
===[[Rheumatoid arthritis]]===
*75mg PO TID or 50mg PO qid or 200mg ER PO daily
**Max: 300mg/day
===[[Dysmenorrhea]]===
*50mg PO q6-8h
**Max: 300mg/day
===Anti-inflammatory uses===
*50-100mg PO TID x7-14 days
**Max: 300mg/day

==Pediatric Dosing==
*Pediatric safety for this drug has not yet been established

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Caution advised in 1st trimester for risk of embryo-fetal toxicity
*Avoid use starting at 30 wk gestation for risk of premature fetal ductus arteriosus closure
*Caution advised in female pts trying to conceive

===Lactation risk===
*Consider alternative while breastfeeding

===Renal Dosing===
*Adult: 
**Mild Impairment: Max 150 mg/day
**CrCl <25: Max 100 mg/day
**HD/PD: No supplement
*Pediatric: Not defined

===Hepatic Dosing===
*Adult: Max 100 mg/day with hepatic impairment
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug
*[[ASA]] or [[NSAID]]-induced [[asthma]] or [[urticaria]]
*Pregnancy starting at 30wk gestation
*CABG surgery periop use
*Aspirin triad

==Adverse Reactions==
===Serious===
*GI bleeding, perforation, ulcer
*[[MI]], [[Stroke]], [[HTN]], [[CHF]]
*Thromboembolism
*Renal papillary necrosis, nephrotoxicity, hepatotoxicity
*Bronchospasm
*[[Stevens-Johnson syndrome]], [[Toxic epidermal necrolysis]]
*[[Anemia]], blood dyscrasias, prolonged bleeding time
*[[Hyperkalemia]]
===Common===
*[[Dyspepsia]], [[nausea]], abdominal pain
*[[Constipation]]
*[[Headache]], [[dizziness]], somnolence
*[[Rash]], peripheral edema, fluid retention
*[[Tinnitus]], photosensitivity
*Ecchymosis
*Delayed ovulation

==Pharmacology==
*Half-life: 2.1h
*Metabolism: Liver extensively, tissues
*Excretion: Urine 80% (<10% unchanged)

==Mechanism of Action==
*Inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

==Comments==


==See Also==
*[[NSAIDs]]
*[[NSAID toxicity]]

==References==
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[[Category:Pharmacology]]