Ver el código de «Jarisch-Herxheimer reaction»

==Background==
*A systemic reaction caused by reaction to endotoxins released by the death of harmful organisms within the body
*Occurs following antibiotic treatment for a number of spirochetal and bacterial infections (classically described in the treatment of syphilis) 
*Can also occur following treatment of tick-borne relapsing fever (TBRF) or [[Lyme disease]] 
*Both [[penicillin]] and [[tetracycline]] can induce JHR
*Resembles bacterial sepsis. 
*Tends to occur within two hours of antibiotic administration
**Lasts for a few hours or up to a day 
*Mortality rate from JHR in louse-borne relapsing fever (LBRF) in the absence of adequate monitoring and resuscitation measures is ~5%.

==Clinical Features==
[[File:Jarisch-Herxheimer reaction in patient (cropped).jpg|thumb|Jarisch–Herxheimer reaction in a person with syphilis.]]
''Occurs 2 to 6 hours after treatment started; symptoms can last for 24 hours''
*Malaise
*[[Fever]]
*Rigors
*Flushing (due to vasodilation)
*[[Hypotension]]
*Tachycardia
**Tachycardia and hyperventilation are accompanied by hypertension, and then by a drop in blood pressure due to vasodilation and declining peripheral pulse.

==Differential Diagnosis==
*[[Sepsis]]

==Evaluation==
*Typically a clinical diagnosis

==Management==
*Reassurance
*[[Acetaminophen]]

==Disposition==
*Outpatient

==See Also==


==References==
<References/>


[[Category:Pharmacology]]
[[Category:ID]]