Ver el código de «Inhaled nitric oxide»

==Administration==
*Type: Inhalational agent
*Dosage Forms: Metal cylinders, 100 ppm and 800 ppm
*Routes of Administration: Inhaled
*Common Trade Names: INOmax

==Adult Dosing==
5 - 80 ppm 

==Pediatric Dosing==
20 ppm 

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Unknown
===Renal Dosing===
*Adult:
*Pediatric:
===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Hypotension
*Inhibits platelets - bleeding
*Rebound htn and hypoxia
*Renal failure

===Common===
*Hypotension
*Withdrawal

==Pharmacology==
*Half-life: 5 seconds
*Metabolism: reacts with oxyhemoglobin to form methemoglobin and nitrate, and also reacts with deoxy-hemoglobin. 
*Excretion: Renally; 70% of inhaled NO excreted within 48 hrs as nitrate in urine

==Mechanism of Action==
*Acts via diffusion from alveoli
*Relaxes smooth muscle of pulmonary vessels via conversion of GTP to cGMP, which activates a phosphorylatio cascade
*Enhances V/Q matching by increasing blood flow to well-ventilated areas of lung
*Decreases PVR
*Decreases PA pressure

==Indications==
*Pulmonary hypertension of newborn
*Pulmonary hypertension of adults
*Cystic Fibrosis
*ARDS
*Right heart failure (post-VAD, transplant, post cardiac surgery)
*Graft failure post lung transplant

==Comments==

==See Also==

==References==
*Ichinose F, Roberts JD Jr, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29;109(25):3106-11. Review. PubMed PMID: 15226227. 
*Medscape
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[[Category:Pharmacology]]