Ver el código de «Indomethacin»

==General==
*Type: [[NSAID]]
*Dosage Forms: PO (Generic in 25 and 50mg tabs)
*Common Trade Names: Indocin

==Adult Dosing==
===[[Preterm labor]]/Tocolysis===
*50-100mg loading dose, 25mg q4-6 hrs for 48 hrs

[[Osteoarthritis]]: 
*25mg PO BID-TID, max 200mg/day, give with food

[[Gout and Pseudogout]]:
*50mg PO TID, taper dose rapidly

[[Ankylosing Spondylitis]]:
*25mg PO bid-tid, max 200mg/day

[[Rheumatoid Arthritis]]:
*25mg PO bid-tid, max 200mg/day

==Pediatric Dosing==

[[Patent ductus arteriosus]]:
*<48 hour old: start 0.2mg/kg IV x 1, then 0.1mg/kg q12-24h x 2
*2-7 days old: Start 0.2mg/kg IV x 1, then 0.2mg/kg q12-24h x 2
*> 7 days old: Start 0.2mg/kg IV x 1, then 0.25mg/kg q12-24h x 2

[[Rheumatoid_arthritis|Rheumatoid Arthritis]]
*1-2mg/kg/day PO divided BID-QID, max 4mg/kg/day up to 150-200mg/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*Lactation: probably safe
*Renal Dosing
**Adult: no adjustment
**Pediatric: no adjustment
*Hepatic Dosing
**Adult: not defined, caution advised if hepatic impairment
**Pediatric: not defined, caution advised if hepatic impairment

==Contraindications==
*Allergy to class/drug
*ASA or NSAID-induced ashtma or urticaria
*Pregnancy 3rd trimester
*Infection, untreated (neonates)
*Active bleeding (neonates)
*Thrombocytopenia (neonates)
*Coagulation Disorder (neonates)
*Necrotizing enterocolitis (neonates)
*renal impairment, significant (neonates)
*Pulmonary atresia (neonates)
*Tetralogy of Fallot, severe (neonates)
*Aortic coarctation, severe (neonates)
*CABG surgery period use
*caution if cardiovascular disease
*caution if hypertension
*caution if CHF
*caution if fluid retention
*caution if GI bleeding or ulcer history
*caution in elderly patients
*caution if dehydration
*caution if sepsis
*caution if asthma
*caution if prolonged use

==Adverse Reactions==
===Serious===
*pulmonary hemorrhage (neonates)
*[[GI bleeding]]
*GI perforation/ulcer
*[[MI]]
*Stroke
*Thromboembolism
*hypertension
*[[CHF]]
*Renal Papillary Necrosis
*[[Acute Renal Failure]]
*Hepatotoxicity
*[[Steven_Johnson_syndrome|Steven-Johnson syndrome]]
*Anemia
*[[Thrombocytopenia|Thrombocytopenia, neonates]]
*hyponatremia (neonates)
*hyperkalemia (neonates)

===Common===
*dyspepsia
*nausea
*abdominal pain
*constipation
*headache
*dizziness
*rash
*ALT,AST elevation
*fluid retention
*tinnitus
*corneal deposits
*photosensitivity

==Pharmacology==
*Half-life: 4.5 hours, 12-21 hours in neonates
*Metabolism:  Liver; CYP450, 2C9 substrate
*Excretion: urine 60%, feces 33%
*Mechanism of Action: exact mechanism unknown, inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis


==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

{{#ask:[[Has DrugName::Indomethacin]]
 |?Has Indication=Indication
 |?Has Dose=Dose
 |?Has Context=Context
 |?Has Route=Route
 |?Has Population=Population
 |format=table
 |headers=plain
 |mainlabel=-
 |sort=Has Indication
 |limit=50
}}

==See Also==
*[[NSAID toxicity]]

==References==
<references/>

[[Category:Pharmacology]]