Ver el código de «Hyoscyamine»

==Administration==
*Type: [[Anticholinergic]]
*Dosage Forms: TAB 0.125mg; SL TAB: 0.125mg; INJ: 0.5 mg/mL; Drops 0.125 mg/mL
*Routes of Administration: Oral, sublingual, IM/IV
*Common Trade Names: Levsin

==Adult Dosing==
===GI Tract spasm===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===Bladder spasm===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===[[IBS]], adjunct tx===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===[[PUD]], adjunct tx===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===[[Parkinson's disease]], adjunct tx===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===Biliary colic, adjunct tx===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===Renal colic, adjunct tx===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===[[Rhinitis]]===
*0.125-0.25 mg PO/SL q4h prn
**Max: 1.5 mg/day
===Diagnostic procedures===
*0.25-0.5mg SC/IM/IV x1
===Anesthesia adjunct===
*5mcg/kg SC/IM/IV x1
===Surgery adjunct===
*0.125 mg IV prn
===Cholinesterase overdose===
*Give 0.3-0.6 mg IV for each 0.5-2 mg neostigmine or physostigmine

==Pediatric Dosing==
===[[Colic]], infantile===
*<2 yo, 3.4-4.9 kg
**4 drops PO q4h prn
*<2 yo, 5-6.9 kg
**5 drops PO q4h prn
*<2 yo, 7-9.9 kg
**6 drops PO q4h prn
*<2 yo, >10 kg
**8 drops PO q4h prn
===Bladder or GI Tract spasm===
*2-11 yo
**0.0625-0.125 mg PO/SL q4h prn
*12+ yo
**0.125-0.25 mg PO/SL q4h prn
===Anesthesia adjunct===
*>2 yo
**5 mcg/kg SC/IM/IV x1
==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: C
*Lactation risk: Caution advised
===Renal Dosing===
*Adult: Caution advised
*Pediatric: Caution advised
===Hepatic Dosing===
*Adult: Caution advised
*Pediatric: Caution advised

==Contraindications==
*Allergy to class/drug
*Glaucoma
*GI obstruction or ileus
*Intestinal atony in elderly pts
*[[Ulcerative colitis]]
*Obstructive uropathy
*Prostatic hypertrophy
*[[MI]]
*Unstable cardiovascular status
*Autonomic neuropathy
*[[Toxic megacolon]]
*[[Myasthenia gravis]]

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Heat stroke]]
*IOP increase
*[[Psychosis]], anticholinergic
*[[Hallucinations]]

===Common===
*Xerostermia
*Dry eyes, blurred vision, mydriasis, cycloplegia
*Urinary retention, [[constipation]], [[nausea]], [[vomiting]]
*Confusion, impaired memory, excitement, nervousness
*[[Tachycardia]], [[palpitations]]
*Anhidrosis, flushing
*Loss of taste
*[[Headache]], [[Dizziness]]
*[[Ataxia]]
*Drowsiness, weakness, insomnia
*[[Fever]]
*Impotence, lactation suppression
*[[Urticaria]]

==Pharmacology==
*Half-life: 2-3.5 hr (7.5 hr ER form)
*Metabolism: Liver
*Excretion: Urine primarily (30-50% unchanged)

==Mechanism of Action==
*Antagonizes acetylcholine receptors

==Comments==


==See Also==


==References==
<references/>

[[Category:Pharmacology]]