Ver el código de «Humate-P»

==Background==
*Human Plasma-derived von Willebrand Factor
*Contains both vWF and factor VIII

==Indications==
*[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)
*[[Von Willebrand disease]] that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)

==Administration==
*Type: [[blood products]]
*Dosage Forms:
*Routes of Administration:
*Common Trade Names: 

==Adult Dosing==
*[[Von Willebrand disease]]
**Major hemorrhage: loading dose 40-80 IU/kg IV 
**Minor hemorrhage: loading dose 40-50 IU/kg IV
*[[Hemophilia]] A
**Minor hemorrhage: Loading dose 15 IU/kg IV should achieve FVIII:C plasma level ~30% of normal
**Moderate hemorrhage: Loading dose 25 IU/kg IV should achieve FVIII:C plasma level ~50% of normal
**Life-threatening hemorrhage: 40-50 IU/kg IV initially, followed by 2-25 IU q8-12hr to maintain FVIII:C level at 80-100% of normal

==Pediatric Dosing==
*[[Von Willebrand disease]]
**Major hemorrhage: loading dose 40-80 IU/kg IV 
**Minor hemorrhage: loading dose 40-50 IU/kg IV

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Data limited
===Renal Dosing===
*Not delineated
===Hepatic Dosing===
*Not established

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Respiratory distress
*Anaphylaxis
*Thromboembolic events
*Hemolytic anemia (in massive doses)

===Common===
*Pain
*Pruritus
*Rash, urticaria, edema
*Fever/chills, flu-like illness, cough, pharyngitis, rhinitis
*Paresthesia
*Fatigue
*Headache
*Asthenia
*Cellulitis
*Chest pain
*Dyspepsia, nausea/vomiting
*Hepatitis

==Pharmacology==
*Half-life: 10-11h
*Metabolism: 
*Excretion: 

==Mechanism of Action==
*Human derived vWF

==Comments==


==See Also==
*[[Hemophilia]]
*[[VWD]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Heme/Onc]]