Ver el código de «Edoxaban»

==Administration==
*Type: [[Anticoagulant]]
*Dosage Forms: 15, 30, 60 mg
*Routes of Administration: Oral
*Common Trade Names: Savaysa

==Adult Dosing==
===[[Thromboembolism]]/[[stroke]] Prophylaxis===
*60 mg PO QD

===[[DVT]]/[[PE]] Treatment===
*<60 kg
**30 mg PO QD
*>60 kg
**60 mg PO QD

==Pediatric Dosing==
N/A

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D; Avoid use (Risk of maternal hemorrhage and embryo-fetal death up to 49xMRHD based on animal data and risk of maternal/fetal bleeding base don mechanism of action; No known risk of teratogenicity)
*[[Lactation risk categories|Lactation risk]]: L3; Safety unknown

===Renal Dosing===
*Adult:
**Thromboembolism/stroke Prophylaxis
***CrCl > 95: Avoid Use
***CrCl 50-95: No Adjustment
***CrCl 15-50: 30 mg QD
***CrCl <15 (not on HD): Avoid use
**[[DVT]]/PE treatment
***CrCl 15-30: 30 mg QD
***Cr Cl <15 (not on HD): Avoid use
*Pediatric: N/A

===Hepatic Dosing===
*Adult: Child-Pugh Class B or C: Avoid use
*Pediatric: N/A

==Contraindications==
*Allergy to class/drug
*Hypersenstivity to drug/class/component
*Active major bleeding
*CrCl > 95 (non-valvular atrial fibrillation patients)
*CrCl < 15
*Hepatic impairment (Child-Pugh Class B or C)

==Adverse Reactions==
===Serious===
*[[Epidural hematoma]]
*Bleeding, severe
*Thrombosis with premature D/C

===Common===
*Bleeding
*[[Anemia]]
*[[Rash]]
*ALT, AST elevation

==Pharmacology==
*Half-life: 10-14 hr
*Metabolism: Minimal; CYP450: 3A4 substrate
*Excretion: Urine 50%

==Mechanism of Action==
*Factor Xa inhibitor

==Comments==
*Black Box Warnings:
**Reduced Efficacy in non-valvular Afib Pts with CrCl >95mL/min with increased risk for ischemic stroke
**Premature treatment discontinuation increases the risk of increased ischemic event for reasons other than pathological bleeding or course completion
**Epidural/Spinal Hematoma Risk after anesthesia or spinal puncture may result in long-term or permanent paralysis and increases.

==Indications by Condition==
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|?Has Context=Context
|?Has Route=Route
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==See Also==
*[[Anticoagulant reversal for life-threatening bleeds]]
*[[Atrial fibrillation (main)]]

==References==
<references/>

[[Category:Pharmacology]]