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==Administration==
*Type: Respiratory Stimulator
*Dosage Forms: INJ
*Routes of Administration: IV
*Common Trade Names: Dopram

==Adult Dosing==
===Respiratory depression, postanesthesia===
*Intermittent Injection
**0.5-1 mg/kg IV q5min prn
***Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h
*Intermittent infusion
**0.5-1 mg/kg IV
***Max: 4 mg/kg/dose, 3 g/24h
===CNS depression, drug-induced===
*Intermittent Injection
**1-2 mg/kg IV q1-2h prn
*Intermittent infusion
**1-3 mg/kg/h IV up to 2h
===Acute hypercapnia, COPD-assoc.===
*1-3 mg/min IV up to 2h

==Pediatric Dosing==
===Respiratory depression, postanesthesia===
*Intermittent Injection
**0.5-1 mg/kg IV q5min prn
***Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h
*Intermittent infusion
**0.5-1 mg/kg IV
***Max: 4 mg/kg/dose, 3 g/24h
===CNS depression, drug-induced===
*Intermittent Injection
**1-2 mg/kg IV q1-2h prn
*Intermittent infusion
**1-3 mg/kg/h IV up to 2h

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: C
*Lactation risk: No current data to asses risk
===Renal Dosing===
*Adult: Caution advised in significant impairment
*Pediatric: Caution advised in significant impairment
===Hepatic Dosing===
*Adult: Caution advised in significant impairment
*Pediatric: Caution advised in significant impairment

==Contraindications==
*Allergy to class/drug
*Concurrent mechanical ventilation
*Mechanical disorders of ventilation
*[[Seizure]] disorder
*[[Pulmonary embolism]]
*Head injury
*[[Stroke]]
*Cerebral edema
*Cardiovascular impairment, Heart failure, HTN

==Adverse Reactions==
===Serious===
*[[Bronchospasm]], laryngospasm
*[[Arrhythmia]]
*[[HTN]]
*[[Seizure]]
*Hallucinations
*Hemolysis with rapid infusion

===Common===
*[[Fever]], flushing, diaphoresis
*Pruritis, parasthesia
*Mydriasis
*Hallucination
*[[Headache]], [[dizziness]]
*Hyperactivity, involuntary movements, muscle spasms
*[[Seizure]]
*[[Dyspnea]], cough, hyperventilation, [[tachypnea]]
*Phlebitis
*[[Diarrhea]], Urinary incontinence, urinary retention

==Pharmacology==
*Half-life: 3.4h
*Metabolism: Liver
*Excretion: Urine (<5% unchanged)

==Mechanism of Action==
*Acts on peripheral carotid chemoreceptors to stimulate respiration

==Comments==


==See Also==


==References==
<references/>

[[Category:Pharmacology]]