Ver el código de «Chronic myeloid leukemia»

==Background==
*Also known as chronic myelogenous leukemia, chronic myelocytic leukemia
*More common in older patients

==Clinical Features==
''Usually progresses through 3 stages''

===Chronic phase===
*Asymptomatic or indolent, nonspecific symptoms
*Malaise, [[fatigue]], weight loss, low grade [[fever]]
*[[Lymphadenopathy]], splenomegaly

===Accelerated phase===
*Worsening of above symptoms due to progressive [[leukocytosis]]
*Signs/symptoms of [[thrombocytopenia]] (e.g. [[petechiae]], [[hemorrhage|bleeding]]) or [[thrombocytosis]]

===Blast crisis===
*Behaves like [[acute leukemia]]
*Associated with [[Leukostasis and hyperleukocytosis]] and [[Hyperviscosity syndrome]]

==Differential Diagnosis==
{{Oncologic emergencies DDX}}
{{DDX leukocytosis}}

==Evaluation==
*CBC
**[[Leukocytosis]]: usually only moderately elevated in chronic phase (20,000-60,000)
**Mild-moderate [[anemia]]
**Variable platelet counts
*Peripheral smear
*[[DIC]] labs: coags, d-dimer, fibrinogen
*[[Tumor lysis syndrome]] labs: BMP, uric acid, phosphate
*Infectious workup
*Evaluate for complications

==Management==
*See management of [[Leukostasis and hyperleukocytosis]], [[neutropenic fever]], [[hyperviscosity syndrome]], [[DIC]], [[tumor lysis syndrome]], [[thrombocytopenia]], [[anemia]]

==Disposition==
*Can consider discharging asymptomatic patients in chronic phase who have no complications and close follow-up. Otherwise, admit.

==See Also==
*[[Oncologic emergencies]]
*[[Leukostasis and hyperleukocytosis]]
*[[Acute leukemia]]

==External Links==

==References==
<references/>

[[Category:Heme/Onc]]