Ver el código de «Cholestasis of pregnancy»

==Background==
*Caused by combination of hormonal, genetic, and environmental factors --> impaired bile flow --> deposition of bile salts in skin and placenta
*May predispose mothers to [[vitamin K deficiency]] and increase risk of preterm delivery, [[IUFD]], and neonatal [[respiratory distress syndrome]]<ref>http://bestpractice.bmj.com/topics/en-us/800</ref>

{{Gallbladder disease types}}

==Clinical Features==
*Typically develops in late second and/or 3rd trimester
*Rapidly resolves after delivery
*[[Pruritus]], starts and predominates on palms and soles
*[[RUQ pain]]
*[[Nausea]]
*[[Jaundice]]

==Differential Diagnosis==
{{Jaundice DDX}}

===Pregnancy-specific pruritus===
''see also: [[Rashes of pregnancy]]''
*Pruritus gravidarum
*Atopic eruption of pregnancy
*Polymorphic eruption of pregnancy
*Pemphigoid gestationis
*Prurigo of pregnancy
*Pruritic folliculitis of pregnancy

==Evaluation==
*CBC (rule out thrombocytopenia)
*[[LFTs]]
**Elevated total bile acid concentration
**Aminotransferases usually <2x upper limit of normal
**Alk phos and bili may be elevated
**GGT normal or modestly elevated
**[[RUQ US]] normal, no biliary duct dilation

==Management==
*Ursodeoxycholic acid ([[ursodiol]]) 300mg TID until delivery
*OBGYN follow-up

==Disposition==
*Discharge with OBGYN follow-up

==See Also==


==External Links==


==References==
https://www.uptodate.com/contents/intrahepatic-cholestasis-of-pregnancy
<references/>
[[Category:OBGYN]] [[Category:GI]]