Ver el código de «Chlorpromazine»

==Administration==
*Type: [[Antipsychotic]], first generation<ref>Leucht S, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382(9896):951-962. PMID 23810019</ref>
*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets
*Routes of Administration: PO, IM, IV
*Common Trade Names: Thorazine

==Adult Dosing==
===[[Nausea/vomiting]]===
*Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary. 
*IM: 25mg one time. If no hypotension occurs, give 25 to 50mg every 3 to 4 hours as needed, then switch to oral dosage. 
*IV: 2mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.

===[[Hiccups]]===
*Oral: 25 to 50mg 3 to 4 times a day
*IM: If symptoms persist for 2 to 3 days, give 25 to 50mg IM
*IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50mg in 500 to 1000 mL of saline.

===[[Psychosis]]===
*IM: Initial Dose 25 to 50mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed. 
*Oral: Initial Dose: 10 to 25mg orally 3 times a day. Total daily doses should be increased in 20 to 50mg increments every 3 or 4 days until symptoms are controlled.
*Usual Maintenance Dose: 200mg/day orally

==Pediatric Dosing==
''should not be used in children under 6 months''

===[[Nausea/vomiting]]===
*Oral: 0.5 to 1mg/kg/dose every 4 to 6 hours as needed. 
*IM or IV: 0.5 to 1mg/kg/dose every 6 to 8 hours

===Maximum recommended doses===
*less than 5 years (less than 22.7 kg): 40mg/day
*5 and older (22.7-45.5 kg): 75mg/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: drug is excreted in breast milk; patients should discuss with physician risks/benefits if breastfeeding

==Indications==
*[[Nausea/vomiting]]
*intractable [[hiccups]]
*[[psychosis]]

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
*Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.

==See Also==
*[[Antipsychotic toxicity]]

==References==
#Chlorpromazine. Retrieved from http://www.drugs.com/cdi/chlorpromazine.html
#US National Library of Medicine. Chlorpromazine: MedlinePlus Drug Information. Retrieved from https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682040.html.
#P Young. The ICU Drug Manual. ''Chlorpromazine''. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/

[[Category:Pharmacology]]
[[Category:Psychiatry]]