Ver el código de «Ceftolozane/tazobactam»

==General==
*Type: [[Antibiotic]] (cephalosporin/beta-lactamase inhibitor combination)
*Dosage Forms: IV
*Common Trade Names: Zerbaxa

==Adult Dosing==
*1.5 grams (1gm ceftolozane/0.5gm tazobactam) IV q8H

==Pediatric Dosing==
''Safety/efficacy not established in children''

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*Lactation: Infant risk cannot be ruled out
*Renal Dosing: 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment
*Hepatic Dosing: no adjustment

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*C. difficile diarrhea
*Renal impairment
*Hypersensitivity
===Common===
*Nausea, diarrhea
*Headache
*Fever

==Pharmacology==
*Half-life: Ceftolozane- ~3h, Tazobactam- ~1h
*Metabolism: N/A
*Excretion: Renal (100%)

==Mechanism of Action==
*Ceftolozane: cephalosporin- binds to bacterial PCN-binding proteins, thus inhibiting bacterial cell wall synthesis 
*Tazobactam: irreversibly inhibits some penicillinases and cephalosporinases and binds to some chromosomal and plasmid-mediated bacterial beta-lactamases

[[Category:ID]]