Ver el código de «Bowel perforation»

==Background==
[[File:Blausen 0817 SmallIntestine Anatomy.png |thumb|Illustration of GI track]]
*Definition: a full-thickness breach of the intestinal wall, allowing air and/or gastrointestinal contents to enter the surrounding peritoneal cavity
*Can be a potentially life-threatening cause of [[sepsis]] 
*Typically presents acutely (i.e., [[appendicitis]], [[diverticulitis]], perforated [[peptic ulcer]], penetrating [[abdominal trauma|trauma]]) and often requires immediate surgical intervention.  
*When the perforation is immediately contained (i.e., by the omentum or retroperitoneum), it may occasionally present with a more indolent course
**Immunosuppression or systemic corticosteroid therapy may also blunt the inflammatory response resulting in a protracted, indolent presentation.

===Causes<ref>Sabiston, David C.,Townsend, Courtney M.,eds. Sabiston Textbook Of Surgery: The Biological Basis Of Modern Surgical Practice. Philadelphia, PA : Elsevier Saunders, 2012.</ref><ref>Tanner, T., Hall, B., & Oran, J. (2018). Pneumoperitoneum. Surgical Clinics of North America., 98(5), 915–932. https://doi.org/10.1016/j.suc.2018.06.004.</ref>===
* [[Peptic ulcer disease]]
* Malignancy
* [[Diverticulitis]]
* [[Appendicitis]]
* [[Abdominal trauma]] (penetrating > blunt)
* [[Bowel obstruction]]
* [[Intestinal ischemia]]
* [[Foreign body ingestion]]
* [[Necrotizing enterocolitis]] (premature infants)
* Iatrogenic (i.e., endoscopy)

==Clinical Features==	
===Primary Features===
;History
*[[Abdominal pain]], abdominal distention / rigidity
**Occasionally focal if regionally confined (less common)
*[[Nausea]], [[vomiting]], [[fever]], and anorexia often present

;Physical exam
* Perforation with [[peritonitis]]
** Abdominal tenderness, distention
** Involuntary guarding
** Rebound tenderness
* Perforation without peritonitis
** Abdominal tenderness
** Voluntary guarding

===Secondary Features===
*[[Sepsis]] ([[fever]], [[leukocytosis]], [[tachycardia]], [[hypotension]])
*Possible [[sepsis]]-related end-organ dysfunction (i.e., [[ARDS]], [[renal failure]])

==Differential Diagnosis==
* [[Acute myocardial infarction]]
* [[Intestinal obstruction]] 
* Acute [[mesenteric ischemia]] 
* [[Mesenteric venous thrombosis]] 
* [[Pelvic inflammatory disease]] 
* [[Tubo-ovarian abscess]] 
* [[Pancreatitis]] 
* Ruptured [[ectopic pregnancy]] 
* [[Spontaneous bacterial peritonitis]]

==Evaluation<ref>Sabiston, David C.,Townsend, Courtney M.,eds. Sabiston Textbook Of Surgery: The Biological Basis Of Modern Surgical Practice. Philadelphia, PA : Elsevier Saunders, 2012.</ref><ref>Tanner, T., Hall, B., & Oran, J. (2018). Pneumoperitoneum. Surgical Clinics of North America., 98(5), 915–932. https://doi.org/10.1016/j.suc.2018.06.004.</ref>==
[[File:Free air2010.png|thumb|Free air under the right diaphragm from a perforated bowel.]]
[[File:sub free gas.jpg|thumb|Subdiaphragmatic free gas. <ref>Case courtesy of Dr Rahul Kulkarni, https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/21444">rID: 21444</ref>.]]
[[File:large bowel perf.jpg|thumb|Large bowel perforation.<ref>Case courtesy of Dr Ian Bickle, "https://radiopaedia.org/">Radiopaedia.org</a>. From the case < href="https://radiopaedia.org/cases/55375">rID: 55375</ref>.]]
[[File:duodenal perf.jpg|thumb|Duodenal perforation.<ref>Case courtesy of Dr Ian Bickle,  "https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/55491">rID: 55491</ref>.]]
===Workup===
*CBC, BMP, PT/PTT, [[LFTs]], lipase, T&S
*Blood cultures (as long as this does not delay the initiation of antimicrobial therapy)
* Imaging (use only if physical exam is non-specific, exam findings of peritonitis warrant immediate surgical consultation):
** X-ray vs CT abdomen/pelvis with IV contrast (and PO contrast if possible)
***	IV contrast improves soft tissue resolution and improves diagnostic accuracy and should be considered even in the presence of acute kidney injury.
***	PO contrast improves bowel resolution and identification of perforation. Presence of PO contrast may help to distinguish intra-abdominal abscesses from adjacent bowel.

===Diagnosis===
* Physical exam vs. imaging

==Management==
===General Treatment===
*NPO<ref>Sabiston, David C.,Townsend, Courtney M.,eds. Sabiston Textbook Of Surgery: The Biological Basis Of Modern Surgical Practice. Philadelphia, PA : Elsevier Saunders, 2012.</ref>
*Surgical consult<ref>Sabiston, David C.,Townsend, Courtney M.,eds. Sabiston Textbook Of Surgery: The Biological Basis Of Modern Surgical Practice. Philadelphia, PA : Elsevier Saunders, 2012.</ref>
*IV [[fluid resuscitation]]<ref>Rhodes, A., Evans, L.E., Alhazzani, W. et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med 43, 304–377 (2017). https://doi.org/10.1007/s00134-017-4683-6.</ref>
** 	Resuscitation guidelines for [[sepsis]] (taken from the Surviving Sepsis Campaign 2016 recommendations):
*** 	For sepsis-induced hypoperfusion, administration of 30 mL/kg of IV isotonic crystalloid within first 3 hrs 
****	Additional fluid resuscitation should be guided by frequent reassessment of hemodynamic status
*** 	Guide resuscitation to normalize lactate in patients with elevated lactate levels as a marker of tissue hypoperfusion
*** 	Initial target mean arterial pressure (MAP) of 65 mmHg in patients with [[septic shock]] requiring vasopressors

===Broad-Spectrum [[Antibiotics]]<ref>Joseph S. Solomkin, John E. Mazuski, John S. Bradley, Keith A Rodvold, Ellie J.C. Goldstein, Ellen J. Baron, Patrick J. O'Neill, Anthony W. Chow, E. Patchen Dellinger, Soumitra R. Eachempati, Sherwood Gorbach, Mary Hilfiker, Addison K. May, Avery B. Nathens, Robert G. Sawyer, John G. Bartlett, Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America, Clinical Infectious Diseases, Volume 50, Issue 2, 15 January 2010, Pages 133–164, https://doi.org/10.1086/649554.</ref>===
''Start as soon as possible; ideally within the first hour''
* Community-acquired: 
**	Therapy should target enteric gram-negative aerobic and facultative bacilli, obligate anaerobic bacilli, and enteric gram-positive streptococci
**Adult regimen:
***'''Mild to moderate severity community acquired GI perforation''':
**** '''Single agent''': [[Cefoxitin]], [[ertapenem]], [[moxifloxacin]], [[tigecycline]], or [[ticarcillin/clavulanic acid]] 
**** '''Combination therapy''':
***** [[Cefazolin]], [[cefuroxime]], [[ceftriaxone]], [[cefotaxime]], [[ciprofloxacin]], or [[levofloxacin]] -AND- 
***** [[Metronidazole]]
*** 	'''High risk/severity community acquired GI perforation''': 
**** '''Single agent''': [[Imipenem-cilastatin]], [[meropenem]], [[doripenem]], or [[piperacillin/tazobactam]] 
**** '''Combination therapy''': [[Cefepime]], [[ceftazidime]], [[ciprofloxacin]], or [[levofloxacin]] -AND- 
**** [[Metronidazole]]
** 	Pediatric regimen:
*** 	'''Community acquired GI perforation''': 
**** '''Single agent''': [[Ertapenem]], [[meropenem]], [[imipenem-cilastatin]], [[ticarcillin/clavulanate]], and [[piperacillin/tazobactam]]
**** '''Combination therapy''':
***** [[Ceftriaxone]], [[cefotaxime]], [[cefepime]], or [[ceftazidime]], each in combination with [[metronidazole]]
***** [[Gentamicin]] or [[tobramycin]], each in combination with [[metronidazole]] or [[clindamycin]], and with or without [[ampicillin]]
* 	Iatrogenic/hospital-associated perforation: Therapy should be driven by local microbiologic results.
** 	Drug-resistant bacteria regimen (common in hospital-associated perforation):
*** 	'''<20% Resistant [[Pseudomonas aeruginosa]], ESBL-producing [[Enterobacteriaceae]], [[Acinetobacter]], or other MDR [[GNB]]''': 
**** '''Single agent''': [[Carbapenem]], [[piperacillin-tazobactam]] 
**** [[Ceftazidime]] or [[cefepime]], each in combination with [[metronidazole]]
*** 	'''ESBL-producing [[Enterobacteriaceae]]''': [[Carbapenem]], [[piperacillin/tazobactam]], or [[aminoglycoside]]
*** 	'''[[P. aeruginosa]] >20% resistant to [[ceftazidime]]''': [[Carbapenem]], [[piperacillin/tazobactam]], or [[aminoglycoside]]
*** 	'''[[MRSA]]''': [[Vancomycin]] only 
* '''Fungal infection''': Antifungal therapy for patients with severe community-acquired or health care-associated infection is recommended if candida is grown from intra-abdominal cultures ([[fluconazole]]; echinocandins for triazole-resistant species)

==Disposition==
* Admission (typically directly to operating room)<ref>Sabiston, David C.,Townsend, Courtney M.,eds. Sabiston Textbook Of Surgery: The Biological Basis Of Modern Surgical Practice. Philadelphia, PA : Elsevier Saunders, 2012.</ref>

==See Also==
*[[Sepsis]]

==External Links==


==References==
<references/>

[[Category:Surgery]]
[[Category:GI]]