Ver el código de «Benztropine»

==Administration==
*Type: Anticholinergic
*Dosage Forms: tablet, injectable solution
*Dosage Strengths: tablet: 0.5, 1, 2mg; injectable solution: 1mg/mL
*Routes of Administration: IV, IM, oral
*Common Trade Names: Cogentin

==Adult Dosing==
*Extrapyramidal disease: 1-4 mg IV/IM/PO 1-2 times daily
*Parkinsonism: 0.5 mg IM/IV/PO daily, titrate up in 0.5mg increments
==Pediatric Dosing==
*Contraindicated children <3 years old. Otherwise, same as adult dosing
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal: no adjustment
*Hepatic: no adjustment

==Contraindications==
*Allergy to class/drug
*Age <3 years
==Adverse Reactions==
===Serious===
*Psychosis, confusion, hallucinations
*Hyperpyrexia, heat stroke, anhidrosis
*Paralytic ileus
===Common===
*Tachycardia
*Constipation, nausea, xerostomia
*Blurry vision
*Urinary retention

==Pharmacology==
*Half-life: duration of action is around 24 hours
*Metabolism: 
*Excretion: 

==Mechanism of Action==
*Anticholinergic, reduces imbalance between acetylcholine and dopamine

==Comments==

==Indications by Condition==
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==See Also==
*[[Extrapyramidal reaction]]
*[[Dystonic reaction]]
*[[Antipsychotics]]
*[[Anticholinergics]]

==References==
*2019 American Geriatrics Society Beers Criteria Update Expert Panel. American Geriatrics Society 2019 updated AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019;67(4):674-694. doi: 10.1111/jgs.15767. [PubMed 30693946]
*Bellman MH. Treatment of phenothiazine drug intoxication with benztropine. Arch Dis Child.1974;49(8):664-665. [PubMed 4424791]
*Benztropine tablets [prescribing information]. Livonia, MI: Major Pharmaceuticals; October 2017.
*Brocks DR. Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci. 1999;2(2):39-46. [PubMed 10952768]
*Cogentin (benztropine) injection [prescribing information]. Lake Forest, IL: Akorn Inc; May 2013.
*Duncan MA, Nikolov NM, and O’Kelly B, “Acute Chorea Due to Ondansetron in an Obstetric Patient,” Int J Obstet Anesth, 2001, 10(4):309-11. [PubMed 15321589]
*Falterman CG, Richardson CJ. Small left colon syndrome associated with maternal ingestion of psychotropic drugs. J Pediatr. 1980;97(2):308-310. [PubMed 740090]
*Habre W, Wilson D, Johnson CM. Extrapyramidal side-effects from droperidol mixed with morphine for patient-controlled analgesia in two children. Paediatr Anaesth. 1999;9(4):362-364. [PubMed 10411778]
*Joseph MM, King WD. Dystonic reaction following recommended use of a cold syrup. Ann Emerg Med. 1995;26(6):749-751. [PubMed 7492048]
*Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB; Schizophrenia Patient Outcomes Research Team (PORT). The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2009. Schizophr Bull. 2010;36(1):94-103. doi: 10.1093/schbul/sbp130. [PubMed 19955388]

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[[Category:Pharmacology]]