Ver el código de «Baloxavir marboxil»

==Administration==
*Type: [[Antiviral]] 
*Dosage Forms: 20 mg, 40 mg tab
*Routes of Administration: PO
*Common Trade Names: Xofluza

==Indications==
* [[Influenza]]

==Adult Dosing==
* 40-79.9 kg: 40 mg PO x1
**Start within 48 hours of symptom onset
**Avoid co-administration with dairy products, calcium supplements
*>80 mg: 80 mg PO x1
**Start within 48 hours of symptom onset
**Avoid co-administration with dairy products, calcium supplements

==Pediatric Dosing==
*Approved for use in pediatric patients 12 and older
* 40-79.9 kg: 40 mg PO x1
**Start within 48 hours of symptom onset
**Avoid co-administration with dairy products, calcium supplements
*>80 mg: 80 mg PO x1
**Start within 48 hours of symptom onset
**Avoid co-administration with dairy products, calcium supplements

==Special Populations==
*[[Pregnancy Category]]: Not assigned (insufficient data)
*[[Lactation risk]]: Avoid use while breastfeeding

===Renal Dosing===
*Adult and Pediatric: 
**CrCl>50: no adjustment
**CrCl<50 or HD/PD: not defined

===Hepatic Dosing===
*Adult and Pediatric:
**Child-Pugh Class A or B: no adjustment
**Child-Pugh Class C: not defined

==Contraindications==
*Allergy to class/drug
*Pregnancy
*Breastfeeding

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Angioedema]]
*[[Erythema multiforme]]
*[[Urticaria]]

===Common===
*Nausea (Especially in older patients)

==Pharmacology==
*Half-life: 79.1 hours
*Metabolism: liver (CYP450)
*Excretion: Feces (predominant), urine<ref>Baloxavir marboxil [monograph]. Epocrates Version. 20.2 [iPhone]. Epocrates, Inc, San Francisco, CA. Available from https://online.epocrates.com/. Accessed March 18, 2020.</ref>

==Mechanism of Action==
*Inhibits viral polymerase acidic protein endonuclease activity, which inhibits viral replications

==Comments==
''Only approved for patients >12 years old and >40kg in weight, no current safety data exists for pregnancy and breastfeeding.<ref>https://www.cdc.gov/flu/treatment/baloxavir-marboxil.htm</ref> More expensive but one time dosing. Genentech, its creator, states a recent phase III trial has shown it to be effective for prophylaxis but not currently FDA indicated for this.<ref>https://www.gene.com/download/pdf/xofluza_prescribing.pdf</ref>

==See Also==
*[[Influenza]]
*[[Antiviral]]
*[[Tamiflu]]/[[Oseltamivir]]

==References==
<references/>

[[Category:Pharmacology]]