Ver el código de «Aspirin»

==General==
*Type: [[Antiplatelet]], [[NSAID]]
*Dosage Forms: tablet, delayed-release tablet, chewable tablet, enteric-coated tablet, oral chewing gum, extended release capsule
*Common Trade Names: Aspirin, Baby Aspirin, ASA
*Usage: Analgesic, antipyretic, antiplatelet

==Adult Dosing==
*325 to 650mg orally or rectally every 4 hours as needed, not to exceed 4 g/day
*324mg chewable for [[ACS]]
*81mg (baby) Aspirin common daily cardiac risk reduction dose

==Pediatric Dosing==
'''''Avoid use''' in children, especially those with viral syndrome, due to risk of [[Reye syndrome]]''
*Fever, pain 
**>12yo: 325 to 650mg PO or PR q4-6h
*2-11yo: 10 to 15 mg/kg PO or PR q4-6h
*Kawasaki: 80-100 mg/kg/day (divided q4-6h) PO until afebrile 48-72h or day 14, then 3-5mg/kg/day until no evidence of coronary changes 
*Stroke: 1 to 5 mg/kg/day PO
*Juvenile RA: 90-130 mg/kg/day PO divided q4-6h

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C (1st-2nd trimester), D (3rd trimester)
*Lactation: Infant risk cannot be ruled out
*Renal Dosing:  if CrCl <10, avoid use
*Hepatic Dosing: avoid if severe impairment 

==Contraindications==
*Allergy to class/drug
* Syndrome of asthma, rhinitis, and nasal polyps


==Adverse Reactions==
===Serious===
*See [[Aspirin (Salicylate) Toxicity]]
*[[Reye syndrome]] - Children and teenagers should not use this medicine for chicken pox or viral symptoms 
*GI ulcer
*Hemorrhage
*Exudative age-related macular degeneration
*Bronchospasm
*Tinnitus
*Angioedema
===Common===


==Pharmacology==
*Half-life: 20-60m, Salicylic acid: 6h
*Metabolism: Hepatic
*Excretion: Renal, dialyzable
*Mechanism of Action: Irreversible cyclooxygenase inhibitor, thus preventing prostaglandin synthesis and platelet activation


==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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 |?Has Indication=Indication
 |?Has Dose=Dose
 |?Has Context=Context
 |?Has Route=Route
 |?Has Population=Population
 |format=table
 |headers=plain
 |mainlabel=-
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==See Also==
*[[Aspirin (Salicylate) Toxicity]]
*[[Antiplatelet medications]]
*[[Antiplatelet agent reversal]]

==References==
http://www.drugs.com/aspirin.html

<references/>
[[Category:Pharmacology]]