Ver el código de «Argatroban»

==Administration==
*Type: [[Anticoagulant]] (Direct thrombin inhibitor)
*Dosage Forms: injectable solution, ready-to-use injectable
*Dosage Strengths: injectable solution: 100mg/mL; ready-to-use injectable: 50mg/50mL 0.9% NaCl, 125mg/125mL 0.9% NaCl
*Routes of Administration: IV
*Common Trade Names: Acova

==Adult Dosing==
*[[HIT]] with thrombosis: 2 mcg/kg/min IV infusion, titrate to aPTT 1.5-3x baseline value
*Myocardial infarction: 100 mcg/kg IV bolus + 1-3mcg/kg/min IV infusion x 6-72 hours; goal aPTT 50-85 seconds
*Cerebral thrombosis: 60 mg/day continuous IV infusion x 2 days, then 10mg IV BID x 5 days
*Coronary thrombosis prophylaxis after PCI (in patients at risk for [[HIT]]): 350 mcg/kg IV bolus + 25 mcg/kg/min IV continuous infusion; titrate to maintain activated clotting time 300-450 seconds

==Pediatric Dosing==
''Safety/efficacy not established''
*[[HIT]]: 0.75 mcg/kg/min IV infusion; titrate in increments of 0.1-0.25 mcg/kg/min to goal aPTT 1.5-3x baseline level

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: no adjustment
*Hepatic dosing: more frequent dosage adjustments may be needed. For [[HIT]] treatment in moderate-severe liver disease, initial dose 0.5mcg/kg/min

==Contraindications==
*Allergy to class/drug
*Major bleeding

==Adverse Reactions==
===Serious===
*Major bleeding: GI bleeding, retroperitoneal hemorrhage, intracranial hemorrhage, coronary artery hemorrhage, hematuria
*Angina, coronary artery thrombosis, aortic valve stenosis, MI, cardiac arrest
*Sepsis
*Pulmonary edema
===Common===
*Hypotension
*Chest pain
*Nausea/vomiting, diarrhea
*Headache, backache
*Dyspnea
*Fever

==Pharmacology==
*Half-life: 30-51min, prolonged in hepatic impairment
*Metabolism: Hepatic
*Excretion: Mostly fecal

==Mechanism of Action==
*Binds to and directly inhibits thrombin

==Comments==

==See Also==
*[[Coagulopathy (main)]]
*[[Anticoagulant reversal for life-threatening bleeds]]

==References==
<references/>
[[Category:Pharmacology]]