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==Administration==
*Type: [[Antidote]], anti-anginal agent
*Dosage Forms: crushable ampules; liquid for inhalation
*Dosage Strengths: 0.3 mL 
*Routes of Administration: inhalation
*Common Trade Names: Component of Cyanide Antidote Package (Lilly kit)

==Adult Dosing==
*Cyanide toxicity: Crush one to two ampules in gauze, cloth, or a sponge and place under patient's nose, in O2 face mask, or port access of ETT. Patient should inhale deeply for 30s, rest for 30s, and repeat for 2-3 minutes

==Pediatric Dosing==
*As above

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: C
*Lactation risk: Infant risk cannot be ruled out

==Contraindications==
*Allergy to class/drug
*Cerebral hemorrhage, recent severe head trauma

==Adverse Reactions==
===Serious===
*Methemoglobinemia (this is the point when used for cyanide toxicity)
*Raised ICP
*Rased IOP
*Syncope
===Common===
*Orthostatic hypotension, dizziness
*Headache
*Flushing

==Pharmacology==
*Half-life: 
*Metabolism: 
*Excretion: 

==Mechanism of Action==
*Convert the iron in hemoglobin from the ferrous to the ferric form, creating methemoglobinemia. Then, the thiosulfate can become sulfate donor, allowing conversion of cyanide to readily renally excretable form

==Comments==


==See Also==
*[[Cyanide toxicity]]

==References==
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[[Category:Pharmacology]] [[Category:Toxicology]]