Ver el código de «Amphotericin B»

==Administration==
*Type: [[Antifungal]]
*Dosage Forms: powder for injection
*Dosage Strengths: 50mg/vial
*Routes of Administration: IV
*Common Trade Names:  AmBisome, Fungizone "ampho-terrible"

==Adult Dosing==
''Dosing is '''NOT''' interchangeable between different formulations of amphotericin B due to significant variations in pharmacokinetics. Call your institution's pharmacy (or ID) if unsure about correct dose. 


===Indications by Disease===
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==Pediatric Dosing==


===Indications by Disease===
{{#ask: [[Has DrugName::Amphotericin B]] [[Has Population::Pediatric]]
 |?Treats disease=Disease
 |?Has Dose=Dose
 |?Has Context=Context
 |format=table
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==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out 
===Renal Dosing===
*Adult:
*Pediatric:
===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Nephrotoxicity/renal failure, hemorrhagic cystitis
*Anaphylaxis
*Cardiac arrest

===Common===
*Hypokalemia, hypomagnesemia, hyperglycemia (check BMP at least daily)
*Rigors
*Nausea/vomiting, diarrhea
*Anemia
*Rash
*Dyspnea
*Insomnia
==Pharmacology==
*Half-life: Depends on formulation, 1-14 days
*Metabolism: unknown
*Excretion: urine

==Mechanism of Action==
*Binds to ergosterol in fungal cell membranes→ intracellular contents leak out→ cell dies

==Comments==
Amphotericin B is an antifungal agent used to treat severe or disseminated fungal infections (e.g. invasive aspergillosis, [[Cryptococcosis|cryptoccoccal meningitis]], [[coccidioidomycosis]], [[mucormycosis]], fungemia in neutropenic patients). It comes in several formulations; conventional, cholesteryl sulfate complex, lipid complex, and liposomal. It is usually reserved for serious infection due to significant associated toxicities, though the newer formulations tend to be better tolerated.

==See Also==
*[[Antifungals]]
*[[Fungal infections]]

==References==
<references/>
[[Category:Pharmacology]] [[Category:ID]]