Ver el código de «25C-NBOMe»

''Although this article specifically addresses 25C-NBOMe, there are also 25I- and 25B- versions of the compound''
==Background==
[[File:25C-NBOMe.png|thumb|25C-NBOMe]]
[[File:25C-NBOMe blotter.jpg|thumb|Blotter paper containing 25C-NBOMe]]
*2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
*Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime
*Potent partial agonist of 5-HT2A receptor<ref name="pharm">Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.</ref>
*First synthesized in Germany by Ralf Heim in 2004<ref>Heim R. “Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur”. :Entwicklung eines neuen Struktur-Wirkungskonzepts. Berlin, Freie University, Dissertation, 2003</ref>
*Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to [[LSD]]
*Commonly ingested orally or sublingually; can also be taken nasally, parenterally, vaginally, rectally.
*Dose of 50-200 micrograms causes hallucinogenic effects<ref name="pharm"></ref>
*Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours<ref name="pharm"></ref>
*Case reports of ingestions have included overdose symptoms of grand mal seizures and purpuric rash and mydriasis with 25'''B'''-NBOMe variant<ref>Poklis JL. et al. Determination of 4 bromo 2,5 dimethoxy N [2 methoxyphenyl) methyl] benzeneethanamine (25B-NBOMe) in serum and urine by high performance liquid chromatography with tandem mass spectrometry in a case of severe intoxication. Drug Test Anal. 2004;6:764-9</ref>
*The 25I- version of the drug has symptoms described as tachycardia, hallucinations, hypertension, and seizures and agitation.<ref>Poklis J. Devers KG et al. Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)methyl] ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death. Forensic Sci Int. 2014;234:e14-e20</ref>

==Clinical Features==
*Metallic chemical taste
*Sense of numbness of tongue and mouth
*Euphoria
*Visual/Auditory [[hallucinations]]
*Stimulation +/- tremors, bruxism
*[[Serotonin Syndrome]] ([[altered mental status]], [[Hyperthermia]], rigidity, autonomic instability)<ref>Boyer EW, Shannon M. The serotonin syndrome. NEJM. 2005;352:1112-20</ref>
*Confusion
*Agitation
*Vasoconstriction
*[[Nausea and Vomiting]]
*[[Headache]]
*Palpitations
*Diaphoresis 
*[[Dysuria]]
*Hypertension
*Generalized [[Seizure]]
*Mydriasis
*[[Acute Renal Failure]]
*[[Metabolic Acidosis]]

==Differential Diagnosis==
{{Drugs of abuse types}}
{{Hallucinogen types}}

==Evaluation==
{{Hallucinogen workup}}

==Management==
*ABCs
*IV, O2, monitor
*'''Agitation'''
**[[Benzodiazepines]]
**[[Haldol]] for acute agitation
*'''[[Seizure]]'''
**[[Benzodiazepines]]
*[[Hyperthermia]]:
**Passive cooling measures

==Disposition==
*Admit for monitoring on all patients with continuing agitation requiring escalating doses of sedation
*Consider discharge if complete resolution of symptoms

==See Also==
*[[Lysergic acid diethylamide (LSD)]]
*[[Ecstasy (MDMA) toxicity]]
*[[Hallucinations]]
*[[Hallucinogens]]

==References==
<references/>

[[Category:Toxicology]]