Ver el código de «Verapamil»

==Administration==
*Type: [[Calcium channel blocker]]
*Dosage Forms:
*Routes of Administration: IV, PO
*Common Trade Names: 

==Adult Dosing==
*[[Atrial fibrillation]], paroxysmal [[SVT]]
**IV: 5-10mg (0.075-0.15 mg/kg), may give an initial 10mg IV after 30 minutes if inadequate response
**PO: 240-48 mg daily in 3-4 divided doses
*Angina, hypertension: 80-120mg PO 3 times per day
==Pediatric Dosing==
*[[Afib]]/[[flutter]], [[SVT]]
**IV 0.1-0.2 (<1yo) or 0.1-0.3 (>1yo) mg/kg. Repeat after 30 minutes if inadequate response
**PO: 4-10 mg/kg/day in 3 divided doses

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*[[Lactation risk categories|Lactation risk]]:
*Renal dosing: no adjustment
*Hepatic dosing: 20-50% of normal dose

==Contraindications==
*Allergy to class/drug
*Afib/flutter associated with accessory bypass tract, e.g. [[WPW]], [Lown-Ganong-Levine syndrome]]
*[[Cardiogenic shock]], [[hypotension]], EF <30%
*2nd or 3rd degree [[AV block]], [[sick sinus syndrome]]

==Adverse Reactions==
===Serious===
*[[AV block]]
*[[MI]]
*[[Pulmonary edema]]
===Common===
*[[Hypotension]]
*Edema
*[[URI]] or [[flu-like symptoms]]
*[[Dizziness]], [[headache]]
*[[Constipation]]

==Pharmacology==
*Half-life: 4-20 hours
*Metabolism: Hepatic- P450 CYP3A4, CYP1A2, CYP2C8, CYP2C9 and CYP2C18
*Excretion: Renal primarily. Not dialyzable

==Mechanism of Action==
*Inhibits L-type (slow) calcium channels, blocking influx of calcium into myocardial cells
*Reduces systemic vascular resistance, vasodiolates peripheral arteries
==Comments==

==See Also==
*[[Calcium channel blockers]]
==References==
<references/>
[[Category:Pharmacology]]