Ver el código de «Fever of unknown origin (peds)»

==Background==
*Prolonged fever of unknown origin without identified cause generally has favorable prognosis.

==Clinical Features==
*Original definition<ref name="Kaya">Kaya A, Ergul N, Kaya SY, et al. The management and the diagnosis of fever of unknown origin. Expert Rev Anti Infect Ther. 2013 Aug;11(8):805-15.</ref>
**Fever >38.3 C on several occasions
**Lasting for at least 3 weeks
**No clear diagnosis after 1 week inpatient workup
*Newer definition<ref>Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35-51.</ref> - "Prolonged fever" with:
**3 outpatient visits without identifying a cause '''or'''
**3 inpatient days without identifying a cause '''or'''
**1 week of “intelligent and invasive” ambulatory investigation

==Differential Diagnosis==
*'''Infection'''
**Bacterial
***Adenitis
***[[Endocarditis]]
***[[Mastoiditis]]
***Occult [[abscess]]
***[[Pyelonephritis]]
***[[Sinusitis]]
***[[Tb]]
**Viral
***CMV
***Hep A,B, C
***Mono
**Chlamydial
***Lymphogranuloma venereum
***Psittacosis
**Mycoplasmal
**Fungal
***Blastomycosis
***Cysticercosis
***Histoplasmosis
***Rickettsial
****[[Q fever]]
****Rocky Mt
***Parasitic
****Malaria
****Toxo
*'''Non-infectious Inflammatory'''
**JRA
**LSE
**Regional enteritis
**Rheumatic fever
**[[Ulcerative colitis]]
**Vasculitis
*'''Malignancy'''
**Leukemia
**Lymphoma
**Neuroblastoma
**Wilm's tumor
*'''Drug Induced'''
**[[Antibiotics]]
**Anticonvulsants
**Anti TB
**Procainamide
**Quinidine
**Serum sickness
*'''Misc'''
**[[AIDS]]
**CNS
**Environmental
**Factitious
**Familial dysautonomia
**[[Kawasaki]]
**[[PE]]
**Serial infections
**[[Thyrotoxicosis]]

==Evaluation==
*Clinical (preliminary) diagnosis

==Management==
*Treat underlying cause (once identified)
*Empiric treatment generally not recommended

==Disposition==
*Frequently admitted for workup

==See Also==
*[[Pediatric fever of uncertain source]]

==References==
<References/>

[[Category:Pediatrics]]