Ver el código de «Organophosphate toxicity»

==Background==
*Highly lipid soluble: absorbed via dermal, gastrointestinal or respiratory routes
*Irreversibly binds acetylcholinesterase -> accumulation of acetylcholine at sympathetic and parasympathetic receptors -->cholinergic crisis
**Parasympathetic: SLUDGE
*Used as insecticides (malathion) and chemical warfare (sarin, VX)
*Consider in ddx of pt w/ AMS + miotic pupils

==Clinical Features==
*SLUDGE(MM)
**'''S'''alivation, '''L'''acrimation, '''U'''rination, '''D'''iarrhea, '''G'''I pain, '''E'''mesis, '''M'''iosis, '''M'''uscle weakness
*Killers B's
**'''B'''radycardia, '''B'''ronchorrhea, '''B'''ronchospasm

==Diagnosis==
*CBC
**May show leukocytosis
*Lipase
*LFT
*CXR
**Pulmonary edema in severe cases
*ECG
**Ventricular dysrhythmias, torsades, QT prolongation, AV block

==Differential Diagnosis==
{{Weakness DDX}}

{{Chemical weapon DDX}}

==Management==
{{Cholinergic Toxicity Treatment}}

==Disposition==
*Minimal exposure only requires decon and 6-8hr obs

==See Also==
*[[Toxidromes]]
*[[Atropine]]

==References==
*World Health Organization. Environmental Health Criteria No 63. Organophosphorus Pesticides: A General Introduction. World Health Organization, Geneva 1986
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[[Category:Tox]]