Ver el código de «Haloperidol»

==General==
*Type: [[Antipsychotic]], first generation
*Dosage Forms: PO, IM, IV
*Common Trade Names: Haldol

==Adult Dosing==
*Acute [[Agitation]]:
**5-10mg IM, subsequent doses based on patient response dosed every 1 hour
**0.5-10mg IV, depending on degree of agitation; may repeat bolus dose (with sequential doubling of initial bolus dose) q15-30mins until calm achieved

*[[Psychosis]]:
**0.5-2mg PO divided BID-TID, slowly titrate q7days to effect with Max 100mg/day

*Tourette Syndrome:
**0.5-2mg PO divided BID-TID, slowly titrate q7days to effect with Max 100mg/day

*Agitation
**0.5-10mg PO q1-4hrs, Max 100mg/day

==Pediatric Dosing==
*Acute Agitation:
**Injectable safety and effectiveness not established in pediatric patients <12yo

*Psychosis:
**3-12yo - 0.05-0.15mg/kg/day PO divided BID-TID, slowly titrate q7days to effect with Max 0.15mg/kg/day
**>12 - 0.5mg-2mg PO divided BID-TID, slowly titrate q7days to effect with Max 100mg/day

*Tourette Syndrome:
**3-12yo - 0.05-0.075mg/kg/day PO divided BID-TID, slowly titrate q7days to effect with Max 0.15mg/kg/day
**>12 - 0.5mg-5mg PO divided BID-TID, slowly titrate q7days to effect with Max 100mg/day

*Behavioral Disorders:
**3-12yo - 0.05-0.075mg/kg/day PO divided BID-TID, slowly titrate q7days to effect with Max 0.15mg/kg/day
**>12 - 0.5mg-5mg PO divided BID-TID, slowly titrate q7days to effect with Max 100mg/day

*Agitation:
**3-12yo - 0.01-0.03mg/kg/day PO divided BID-TID, slowly titrate q7days to effect with Max 0.15mg/kg/day
**>12 - 0.5mg-10mg PO divided BID-TID, Max 100mg/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Pregnancy and lactation drug labeling|Lactation risk]]: Unknown
*Renal Dosing
**Adult - none
**Pediatric - none
*Hepatic Dosing
**Adult - Hepatic impairment
**Pediatric - Hepatic impairment

==Contraindications==
*Allergy to class/drug
*Parkinson's Disease
* Caution in QT prolongation

==Adverse Reactions==
===Serious===
*[[Prolonged QT]] → [[Torsades de pointes]] → Sudden Death
*[[Hypotension]]
*[[Neuroleptic malignant syndrome]]
*[[Seizure]]

===Common===
*[[Constipation]] 
*Xerostomia
*Blurred vision
*[[Urinary retention]]
*Leukopenia
*Neutropenia
*Agranulocytosis
*Dystonia/Extrapyramidal Disease
*Blurred Vision

==Pharmacology==
*Half-life: 18 hours
*Metabolism: Hepatic -  Glucuronidation and CYP3A4-mediated 
*Excretion: Urine and Fecal
*Mechanism of Action: blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain, depressing depresses the release of hypothalamic and hypophyseal hormones leading to a depressed reticular activating system

==Comments==



==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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 |?Has Indication=Indication
 |?Has Dose=Dose
 |?Has Context=Context
 |?Has Route=Route
 |?Has Population=Population
 |format=broadtable
 |headers=plain
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==See Also==
*[[Antipsychotic toxicity]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Psychiatry]]