Ver el código de «Ceftazidime»

==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::cephalosporin]]
*Dosage Forms: injectable solution, powder for injection
*Dosage Strengths: injectable solution: 20mg/mL, 40mg/mL; powder for injection: 500mg, 1g, 2g, 6g
*Routes of Administration: IV, IM
*Common Trade Names: Fortaz, Tazicef, Tazidime

==Adult Dosing==
===Indications by Disease===
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|?Has Dose=Dose
|?Has Context=Context
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==Pediatric Dosing==
===Indications by Disease===
{{#ask: [[Has DrugName::Ceftazidime]] [[Has Population::Pediatric]]
|?Treats disease=Disease
|?Has Dose=Dose
|?Has Context=Context
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==Special Populations==
*Pregnancy: C; May use during pregnancy
*Lactation: No known risk
*Renal Dosing
**Adult
***CrCl 31-50: Give q12h
***CrCl 16-30: Give q24h
***CrCl 6-15: 1 g x1, then 500mg q24h
***CrCl   <5: 1 g x1, then 500mg q48h
***HD: 1 g x1, then give 1 g after dialysis, no supplement
***PD: 1 g x1, then 500mg q24h, no supplement
**Pediatric
***CrCl 30-50: Give q12h
***CrCl 10-29: Give q24h
***CrCl   <10: Give q48h
***HD/PD: No supplement

*Hepatic Dosing
**Adult: No adjustment
**Pediatric: No adjustment

==Contraindications==
*Allergy to class/drug
*Caution:
**Hypersensitivity to [penicillin]
**Renal impairment
**Concurrent nephrotoxic agent
**Seizure disorder
**Recent abx-associated colitis

==Adverse Reactions==
===Serious===
*[[Seizure]]
*[[Agranulocytosis]]
*[[Thrombocytopenia]]
*[[Anemia]], hemolytic
*[[Anaphylaxis]]
*C. difficile-associated diarrhea

===Common===
*[[Diarrhea]]
*[[Nausea]]/[[Vomiting]]
*Abdominal pain
*[[Rash]]
*Pruritus
*Urticaria
*[[Headache]]
*Dizziness
*ALT, AST elevation
*BUN, Cr elevation

==Pharmacology==
*Half-life: 1.9h
*Metabolism: Minimal
*Excretion: Urine primarily
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||I
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||X1
|-
| ||[[MSSA]]||I
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||I
|-
| ||[[N. meningitidis]]||I
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||'''S'''
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||'''S'''
|-
| ||Serratia marcescens||X1
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||'''S'''
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||I
|-
| ||[[Pseudomonas aeruginosa]]||'''S'''
|-
| ||[[Burkholderia cepacia]]||'''S'''
|-
| ||[[Stenotrophomonas maltophilia]]||I
|-
| ||[[Yersinia enterocolitica]]||I
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||'''S'''
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||'''S'''
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||'''S'''
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]