Ver el código de «Ceftriaxone»

==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: injectable solution, powder for injection
*Dosage Strengths: injectable solution: 1g/50mL, 2g/50mL; powder for injection: 250mg, 500mg, 1g, 2g, 10g, 100g
*Routes of Administration: IV, IM
*Common Trade Names: Rocephin

==Adult Dosing==
===Indications by Disease===
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==Pediatric Dosing==
===Indications by Disease===
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==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*Lactation: Probably safe
*Renal Dosing
**Adult
***Renal failure: No initial adjustment, monitor serum levels
***Hemodialysis: give dose after dialysis, no supplement
***Peritoneal Dialysis: 750mg q12h
**Pediatric
***CrCl <10: give q24h
***Hemodialysis: 50mg/kg q24, no supplement
***Peritoneal Dialysis: 50mg/kg q24, no supplement
*Hepatic Dosing
**Adult
***Hepatic and renal disease: max 2g/day, unless closely monitoring serum levels
**Pediatric
***May requrire dose adjustment but specific dosing not defined

==Contraindications==
*Allergy to class/drug (see also [[Cephalosporin Cross-reactivity]])
*Patients <1 month old
**Hyperbillirubinemia
**IV calcium containing product
**If a 3rd generation cephalosporin is required, consider using Cefotaxime instead

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*Broncospasm
*[[Stevens-Johnson Syndrome]]
*[[Toxic Epidermal Necrolysis]]
*Erythema multiforme
*Serum sickness
*Pneumonitis
*Neutropenia
*Leukopenia
*Hemolytic anemia
*[[Thrombocytopenia]]
*Hypoprothrombinemia
*Agranulocytosis
*Superinfection
*[[Clostridium difficile]]
*Colitis
*Billiary/gallbladder sludge
*[[Jaundice]]
*[[Pancreatitis]]
*[[Seizures]]
*[[Nephrolithiasis]]
*Lung/kidney calcium precipitate (neonates)

===Common===
*Local infection site reaction
*Eosinophilia
*Thrombocytosis
*Transaminitis
*[[Diarrhea]]
*Leukopenia

==Pharmacology==
*Half-life: 5.8-8.7h, 15h (CrCl 5-15)
*Metabolism: CYP450
*Excretion: Primarily urine
*Mechanism of Action: bactericidal; inhibits cell wall synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||X1
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||I
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||'''S'''
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||'''S'''
|-
| ||Serratia marcescens||X1
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||'''S'''
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||'''S'''
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||I
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||'''S'''
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||'''S'''
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||I
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||'''S'''
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:ID]]