Ver el código de «African trypanosomiasis»

==Background==
*AKA sleeping sickness
*Caused by ''Trypanosoma brucei gambiense'' and ''Trypanosoma brucei rhodesiense''
*Transmitted by the tsetse fly

==Clinical Features==
[[File:PMC5373517 pntd.0005324.g001.png|thumb|Cervical LAD in African trypanosomiasis]]
[[File:AcuteSleepingSickness.jpg|thumb|Typical fine-spotted pink rash of acute African trypanosomiasis on the skin of the abdomen (”trypanid rash”).]]
*Initial features
**Localized inflammatory reaction after tsetse fly bite
**Painless chancre 2-3 days later, lasts 2-3 weeks
*Systemic disease
**Intermittent [[Fever]]
**Malaise, wasting
*CNS involvement
**Behavioral changes
**[[Encephalitis]]
**[[Coma]]
**Death
*Other complications
**Hemolysis, [[anemia]]
**Pancarditis
**[[Meningoencephalitis]]
*Winterbottom's sign: posterior cervical LAD (Gambiense)

==Differential Diagnosis==
{{Travel Skin Conditions DDX}}

==Evaluation==
*Blood smear to identify parasite
*Parasites can also be found in lymph nodes, chancres, bone marrow, or CSF

==Management==
*Consult ID early!
*No CNS involvement
**[[Pentamidine]] or suramin
*CNS involvement
**Melarsoprol, eflornithine, or a combination of nifurtimox and eflornithine

==Disposition==

==See Also==
*[[Parasitic Diseases]]
*[[Travel Medicine]]

==External Links==

==References==
<references/>

[[Category:ID]]
[[Category:Tropical Medicine]]