Ver el código de «Ritonavir»

==Administration==
*Type: [[Antiviral]]
*Dosage Forms: 100 mg
*Routes of Administration: PO
*Common Trade Names: Norvir

==Adult Dosing==
*HIV Treatment
**Protease inhibitor boosting
***100-400 mg/day QD-BID
**Sole protease inhibitor
***600 mg PO BID
***Start with 300 mg PO BID, increased by 200 mg/day every 2-3 days

*HIV post-exposure prophylaxis
**100 mg PO QID
**Part of multi-drug regimen

==Pediatric Dosing==
*HIV Treatment
**Can be given in >1 month old, dosing varies based on other concominant treatments
*HIV post-exposure prophylaxis
**Can be given in >3 years old,  dosing varies based on other concominant treatments

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*HIV: Benefits outweight risk during pregnancy. Avoid oral solution due to alcohol content.

===Lactation risk===
*Avoid breastfeeding

===Renal Dosing===
*Adult: No adjustment
*Pediatric: Not defined, but likely no adjustment as in adults

===Hepatic Dosing===
*Adult:
**Mild-moderate impairment: no adjustment
**Severe impairment: not defined
*Pediatric:
**Mild-moderate impairment: no adjustment
**Severe impairment: not defined
==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Hepatotoxicity
*[[Pancreatitis]]
*GI bleed
*Hypersensitivity reaction
*[[Anaphylaxis]]
*[[Toxic epidermal necrolysis]]
*[[Stevens-Johnson syndrome]]
*PR prolongation/AV block
*Hypercholesterolemia/hypertriglyceridemia
*[[Diabetes mellitus]]/hyperglycemia
*[[Immune reconstitution syndrome]]
*Autoimmune disorders
*[[Hypertension]]
*[[Syncope]]
*Orthostatic hypotension
*Myopathy
*[[Thrombocytopenia]]

===Common===
*Nausea/vomiting
*Diarrhea
*Paresthesia
*Fatigue
*Rash
*Abdominal pain
*Cough
*Dysgeusia
*Oropharyngeal pain
*Dizziness
*AST, ALT, CK elevation
*Edema
*Acne
*Lipodystrophy

==Pharmacology==
*Half-life: 3-5 hours
*Metabolism: Liver (CYP450)
*Excretion: Fecal

==Mechanism of Action==
*Binds to active site of HIV protease, preventing maturation of the virus

==Comments==
A trial of [[lopinavir]]/[[ritonavir]] is currently being done to study use in [[COVID-19]]. So far, studies have not shown significant benefit in time to clinical improvement. Mortality at 28 days is lower but not statistically significant.

==See Also==


==References==
<references/>

[[Category:Pharmacology]]