Ver el código de «Hydrogen sulfide toxicity»

Hydrogen Sulfide Poisoning. Catherine Neal, MD and Alex Koyfman, MD. Department of Emergency Medicine, UT Southwestern Medical Center / Parkland Memorial Hospital, Dallas, Texas, USA

==General Information:==

Colorless, flammable gas

Encountered in following industries: oil, gas, organic decomposition (sewer and manure), roofing asphalt tanks

Most common fatal gas exposure

“Rotten egg” smell which diminishes with high concentrations or prolonged low concentration exposure

Often used in suicide attempts: acidic detergent (toilet bowl cleaner) is mixed with bath salts or pesticides

==Mechanisms of toxicity:==

*Highly lipid soluble

*Disrupts oxidative phosphorylation by inhibiting cytochrome oxidase aa3 (toxicity through cellular asphyxia and impairs ATP production) => lactate accumulation and metabolic acidosis

*Causes hyperpolarization of potassium-mediated channels in neurons

*Potentiates neuronal inhibitory mechanisms

*Alters brain neurotransmitter content and release

==Symptoms:==

*Respiratory: dyspnea, cyanosis, hemoptysis, rales, delayed pulmonary edema

*Ophthalmic: conjunctivitis, corneal ulceration, corneal scarring

*Central nervous system: headache, weakness, disequilibrium, intention tremor, muscle rigidity, loss of consciousness, seizures, coma

*Gastrointestinal: green-gray line on gingiva, nausea, vomiting

*Cardiovascular: chest pain, bradycardia

*Neuropsychiatric: amnesia, lack of insight, disorientation, delirium, dementia
*Death

==Differential Diagnosis:==

Carbon Monoxide Toxicity

Cyanide Toxicity

Hydrocarbon Toxicity

Smoke Inhalation Injury

==Diagnosis:==

*No single test to verify exposure or levels

*ABG: metabolic acidosis and normal oxygen saturation (unless pulmonary edema present)

*Elevated lactate

*Discolored copper coins found on patient may be helpful in diagnosis

==Treatment:==

*Removal from source

*100% oxygen

*Can give nitrite component of cyanide antidote kit (do NOT give the thiosulfate portion): 
**Theoretically increasing methemoglobin formation in blood will cause conversion of sulfide to sulfmethemoglonin (less toxic)
**Sodium nitrite (3% NaNO2) IV over 2-4 minutes
**Adult dose: 10 mL
**Obtain methemoglobin level 30 minutes after dose (desired level < 30%)

*Hyperbaric oxygen therapy (though not proven to have any benefit)

==Disposition:==

*Admission, likely to MICU

*Toxicology consult

==Sources:==

Tintinalli’s Emergency Medicine

Goldfrank’s Toxicologic Emergencies

Medscape

==Clinical Features==
#One of the few chemical asphyxiants that also possesses irritative properities
##Respiratory, ocular irritation
#High conc exposure may result in LOC, seizure, and death after only a few breaths
##Delayed pulm edema and corneal destruction should be anticipated w/ massive exposures

==Treatment==
#Decontamination of skin/eyes
#O2 100% NRB
#Consider giving nitrite component of CN kit (do not give thiosulfate portion)
##Low level MetHb may enhance conversion of sulfide to less toxic sulfmethemoglobin

==Source==
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[[Category:Tox]]