Ver el código de «Acebutolol»

==Administration==
*Type: [[Beta blocker]]
*Dosage Forms: Cap: 200mg, 400mg
*Routes of Administration: Oral
*Common Trade Names: Sectral

==Adult Dosing==
===[[Hypertension]]===
*400-800 mg PO bid
**Max: 1200 mg/day (800mg in elderly pts)
===Ventricular [[arrhythmia]]===
*300-600 mg PO bid
**Max: 1200 mg/day (800mg in elderly pts)

==Pediatric Dosing==
Safety/efficacy not established in pediatric patients

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: Possible risk of intrauterine growth restriction
*Lactation risk: Avoid during breastfeeding

===Renal Dosing===
*Adult:
**CrCl 25-50: Decrease dose 50%
**CrCl <25: Decrease dose 75%
**HD/PD: No supplement
*Pediatric: Not defined
===Hepatic Dosing===
*Adult: Caution advised
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug
*Sinus [[bradycardia]]
*2nd or 3rd degree [[AV block]]
*[[Heart failure]], uncompensated
*[[Cardiogenic shock]]
*Sick sinus syndrome w/o pacemaker
*Breastfeeding
*Avoid abrupt withdrawal

==Adverse Reactions==
===Serious===
*[[CHF]]
*[[Bradycardia]], severe
*[[Heart block]]
*[[Angina]] if abrupt D/C, [[MI]] if abrupt D/C
*Ventricular arrhythmia if abrupt D/C
*Raynaud phenomenon
*[[Bronchospasm]]
*Lupus erythematosus
===Common===
*[[Fatigue]], [[Dizziness]], [[Headache]]
*[[Constipation]], [[Diarrhea]]
*Dyspepsia
*[[Nausea]]
*[[Dyspnea]]
*[[Insomnia]]
*Urinary frequency
*[[Chest pain]]
*Edema
*Abnormal dreams
*[[Rash]]
*[[Arthralgia]]/Myalgia
*Visual disturbance

==Pharmacology==
*Half-life: 3-4 hours (8-13h diacetolol)
*Metabolism: Liver; Production of active metabolite (diacetolol)
*Excretion: Bile/feces/gut wall 50-60%; Urine 30-40% (12-29% unchanged)

==Mechanism of Action==
*Selectively antagonizes beta-1 adrenergic receptors
*Class II antiarrhythmic

==Comments==


==See Also==


==References==
*Acebutolol hydrochloride [prescribing information]. Bridgewater, NJ: Amneal Pharmaceuticals; January 2016
*Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society [published online ahead of print October 30, 2017]. Circulation. 2017. doi: 10.1161/CIR.0000000000000549. [PubMed 29084731]
*American College of Obstetricians and Gynecologists (ACOG), Committee on Obstetric Practice. Committee Opinion No. 623: emergent therapy for acute-onset, severe hypertension during pregnancy and the postpartum period. Obstet Gynecol. 2015;125(2):521-525. [PubMed 25611642]

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[[Category:Pharmacology]]