Ver el código de «Meropenem-vaborbactam»

==Administration==
*Type: [[Carbapenem]]+beta lactamase inhibitor
*Dosage Forms: 2 gram (1 gram each) solution reconstituted
*Routes of Administration: IV
*Common Trade Names: Vabomere

==Adult Dosing==
Complicated UTI (including pyelonephritis)
*4 g IV q8h (administered over 3 hours)

==Pediatric Dosing==


==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
Unknown

===Lactation risk===
*Meropenem is present in breast milk

===Renal Dosing===
*eGFR >50: none
*eGFR 30 to 49: 2 g q8h
*eGFR 15 to 29: 2 g q12h
*eGFR <15: 1 g q12h
ESRD on HD: Administer after HD on dialysis days

===Hepatic Dosing===
None

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*DVT (<1%)
*Increased risk of seizures

===Common===
*Phlebitis
*Headache
*Hypokalemia
*Diarrhea
*Increased ALT/AST
*Infusion site reaction

==Pharmacology==
*Half-life: Meropenem 1.2 hours; Vaborbactam 1.68 hours
*Metabolism: 
*Excretion: Meropenem (urine); Vaborbactam (urine)

==Mechanism of Action==
*[[Meropenem]] inhibits bacterial cell wall synthesis
*Vaborbactam is a beta-lactamase inhibitor that protects meropenem from degradation by KPC

==Comments==
*Cost: 1 g: ~$200

==See Also==

==References==
<references/>

[[Category:Pharmacology]]